Intabio ZT system
The Intabio ZT system couples icIEF separation and UV detection with high-resolution mass spectrometry on the ZenoTOF 7600 system. Experience one integrated workflow with a single, accessible dataset containing the required information to make the right decisions, fast.
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Review Date: 16 Jul 2024 | SCIEX
The Intabio ZT system couples icIEF separation and UV detection with high-resolution mass spectrometry on the ZenoTOF 7600 system. Experience one integrated workflow with a single, accessible dataset containing the required information to make the right decisions, fast.
Monitoring and determining the cause of antibody discoloration
Color is a potential critical quality attribute of protein therapeutics. Undesirable color changes can lead to increased product heterogeneity and concerns about the safety and efficacy of a drug. Hence, the cause of color change in biotherapeutics must be fully understood and reported to regulatory agencies.
This technical note highlights a streamlined solution that combines the power of capillary isoelectric focusing (cIEF) to monitor antibody discoloration and an EAD-based MAM workflow to determine the cause of color change. The cIEF profiles of the time-course forced glycation samples of NISTmAb revealed a significant increase in acidic variants in the discolored samples. EAD-based MAM was employed to identify and quantify the acidic species to assess their role in the discoloration of protein therapeutics.
Intact-level protein analysis and charge-variant identification using the Intabio ZT system
In this video, Dr. Maggie Ostrowski, senior manager of CE-MS product management at SCIEX, discusses features from the Intabio ZT system. The video presents the system's ability to utilize imaged capillary isoelectric focusing (icIEF) to detect and characterize charge variants. The system requires minimal sample preparation and utilizes a platform method with the aim to accelerate development timelines.
Addressing cell line development barriers with advanced analytics
In this SelectScience interview, explore key challenges, analytical solutions and future directions in cell line development
Optimize monoclonal antibody development with icIEF-UV/MS
Scientists at Johnson & Johnson Innovative Medicine are using the Intabio ZT system for the confident characterization of monoclonal antibodies
