ZenoTOF 7600 system
Be extraordinary - welcome to the Zeno revolution, driven by the combined power of the Zeno trap and EAD
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My Experience with SCIEX's Ultimate Mass Spectrometry System
Mass spectrometry
As a researcher in the field of mass spectrometry, I've had the pleasure of using the ZenoTOF 7600 system by SCIEX. This technology has exceeded my expectations in terms of speed, sensitivity, and accuracy. What I love most about the ZenoTOF 7600 is its ability to provide real-time results, enabling me to analyze and identify molecules in record time. Its intuitive user interface and advanced software make it easy for me to operate and analyze data, saving me time and effort. The ZenoTOF 7600's high-resolution capabilities have allowed me to make new discoveries and obtain groundbreaking insights in my research. It has opened up new possibilities in the fields of proteomics, metabolomics, and lipidomics. Overall, I highly recommend the ZenoTOF 7600 to any researcher looking for the ultimate mass spectrometry system. Its power, precision, and user-friendly interface make it a game-changer in the field.
Review Date: 27 Sept 2023 | SCIEX
Great and reliable results.
Metabolomics
Perfect instrument to get metabolomics to the next level with EAD fragmentation.
Review Date: 7 Sept 2023 | SCIEX
Great results and value for money.
Analyze metabolites in tissue samples
Its a high quality and accurate data analysis. Service and application support is very good.
Review Date: 13 Dec 2022 | SCIEX
Great results, can’t live without this instrument!
Characterization of biological products
1. In terms of hardware, EAD technology is multiple mass spectrometry fragmentation technology，it can provide more secondary fragment ions based on free radical fragmentation can be generated, which provides a new dimension for the structural analysis of high resolution mass spectrometry. Furthermore，the updated software is more efficient in handling PTM and so on. 2. Before and after the equipment purchase, they have been standing in my point of view to provide services, and help me to train the talent of mass spectrometry and I hope they keep it up. 3. I originally planned to buy QE Plus, but later CONDUCTED some difficult experiments. After comparing the data processed by different instruments, I found that 7600 could provide more realistic results, which was amazing. Moreover, this device was more affordable than QE Plus.
Review Date: 22 May 2022 | SCIEX
Super
Rd
Mind blowing product with respect to accuracy and sensitivity
Review Date: 12 May 2022 | SCIEX
Great result can’t live without this instrument
Life science and biopharma
10/10
Review Date: 5 May 2022 | SCIEX
Good value for money, very efficient
Protein characterization
Very good
Review Date: 24 Mar 2022 | SCIEX
A powerful leap in proprietary innovation, this high-resolution accurate mass system combines the power of Zeno trap pulsing with EAD fragmentation technology (electron activated dissociation). You are now able to uncover structural information that was previously inaccessible and push the limits of quantification that are achievable with accurate mass.
- Overcome QTOF MS/MS duty cycle deficiencies
- >90% ions injected into the TOF
- Sensitivity gains of up to 5-20x with Zeno trap pulsing
- Identify and quantify low abundance species
- Tunable fragmentation of all molecule types
- Utilize controlled electron activated dissociation (EAD)
- MS/MS scan rates of up to 133Hz
- Improved DDA and high-resolution MRM (MRMRHR)
Master EAD fragmentation for comprehensive characterization of next-gen protein therapeutics
Find out how a groundbreaking electron-activated dissociation (EAD) approach can deliver deeper insights into complex therapeutics, including enhanced isomer identification, glycosylation profiling, and post-translational modification (PTM) analysis.
This SelectScience guide covers:
- How EAD is a step change in fragmentation technology
- Enhanced peptide mapping with collision-induced dissociation (CID) & EAD
- Streamlined single-injection middle-down workflow
- High sequence coverage & confident PTM analysis
- Characterization of O-linked glycosylation
- Enhanced sequence variant analysis
Discover advanced techniques in protein therapeutic development to optimize outcomes and overcome key challenges by downloading your free copy today.
Resource details:
- Document type: SelectScience guide
- Page count: 60
- Read time: 90 mins
- Edition: 1st
A streamlined workflow for the determination of the drug-to-antibody ratio (DAR) of antibody-drug conjugates (ADCs)
In this application note, Intabio highlights an efficient intact protein analysis workflow for determining drug-to-antibody ratios (DARs) of antibody-drug conjugates (ADCs). This workflow leverages high-resolution mass spectrometry (MS) for accurate intact mass measurement in addition to automated protein deconvolution and DAR calculation provided by Biologics Explorer software. Average DAR values of 3.6 and 3.5 were obtained for the glycosylated (native) and deglycosylated forms of trastuzumab emtansine (T-DM1), respectively.
Combining orthogonal glycan analysis techniques for a deeper understanding of a tri-specific protein
Explore the critical role of glycosylation in multispecific proteins and its impact on their function. Michael McKinnon, from Novartis Institutes for Biomedical Research, highlights traditional glycosylation analysis methods and presents a case study on a TriSpecific fusion protein, emphasizing the need for precise glycan localization. The discussion compares Electron-Activated Dissociation (EAD) and Collision-Induced Dissociation (CID) techniques, showcasing their applications in glycan analysis. The ZenoTof 7600 is introduced as a powerful tool for advanced protein characterization, providing deeper insights into glycan structures and modifications.
Addressing cell line development barriers with advanced analytics
In this SelectScience interview, explore key challenges, analytical solutions and future directions in cell line development
Optimize monoclonal antibody development with icIEF-UV/MS
Scientists at Johnson & Johnson Innovative Medicine are using the Intabio ZT system for the confident characterization of monoclonal antibodies
SCIEX launches high-throughput screening solutions at SLAS2024
The Echo MS+ system unlocks enhanced high-throughput screening capability
Top 10 technology launches at ASMS 2022
Catch up on some of the most exciting advancements in mass spectrometry presented at ASMS 2022
SCIEX announces the development of its icIEF-MS technology
New icIEF technology provides a unique and powerful analysis method to address key analytical challenges
