Prometheus Panta for protein stability with particle sizing by NanoTemper Technologies

Manufacturer NanoTemper Technologies  |  Available Worldwide
With the latest in dynamic light scattering (DLS) technology, it is now possible to obtain particle sizing and dispersity information alongside thermal stability and turbidity, all in a single experiment along a thermal denaturation gradient. DLS, nanoDSF (intrinsic fluorescence), and backreflection combine to give you the full picture of your protein’s stability, ideal for every step in the biologics workflow.


Prometheus Panta for protein stability with particle sizing by NanoTemper Technologies product image
Prometheus Panta for protein stability with particle sizing
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Prometheus Panta measures thermal unfolding, particle sizing, and aggregation simultaneously throughout the entire thermal ramp for high-resolution, domain-specific stability characterization of biologics. To do this it uses DLS, nanoDSF, and backreflection technologies to give you a full picture of your candidate’s stability.

Key Features:

  • Measurements in solution and label-free
  • Tyrosine and tryptophan fluorescence
  • Dual UV system: 330 nm and 350 nm fluorescence is detected
  • 48 samples at a time with single capillaries or 24 in capillary chip
  • DLS parameters: Tscattering, Tsize, rH, PDI, kD, D0, average scattering intensity, reversibility of unfolding
  • nanoDSF parameters: Tm, Tonset, Ea, reversibility of unfolding
  • Temperature range: from 15 °C to 95 °C (up to 110 °C with High Temperature Upgrade)
  • Maintenance-free instrument
  • Straightforward handling: Simple sample preparation and intuitive software user interface

Included Backreflection Optics:

 

  • Backreflection optics: aggregation of protein samples is recorded
  • Ultra-high resolution: precisely determine aggregation onset temperatures