MBT STAR®-Carba IVD Kit by Bruker Daltonics

Manufacturer Bruker Daltonics
5.0
/
5.0
  |  16 reviews

Rapid detection of carbapenemase activity via MALDI-TOF MS


MBT STAR<sup>®</sup>-Carba IVD Kit by Bruker Daltonics product image
MBT STAR®-Carba IVD Kit
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Average Rating: 5.0
16 Scientists have reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money


Very reliable method.
Rating: 5.0

  • Application Area: diagnostics kit

"The STAR-Carba kit is a very reliable method to detect carbapenemases, and it finally overcomes several limits shown by other methods."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Very easy to use.
Rating: 5.0

  • Application Area:diagnosic kit

"STAR-Carba is a method very easy to use method, with short handling time."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Very reliable method.
Rating: 5.0

  • Application Area:Carbapenemase resistance screening

"Very reliable method. Sensitive and specific, beyond very rapid, it fills the lack of performance shown by some other methods."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
I'd absolutely recommend it.
Rating: 5.0

  • Application Area:Antibiotic resistance screening

"The most reliable and robust method for carbapenemase detection I have ever tested (and I started in 2010 with MHT). And the most sensitive and specific, Easy to use, very short handling time, automated detection (not operator-depending as it is for several other methods), data stored in case it's needed to check them in a second moment. I'd absolutely recommend it, as the features of the methods make it suitable both for countries with low and high prevalence of carbapenemase-resistant strains."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Reliable, robust, sensitive and specific.
Rating: 5.0

  • Application Area:In Vitro Diagnostics test

"Very innovative and  reliable test, robust, sensitive and specific."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
STAR is a very easy to use test.
Rating: 5.0

  • Application Area:Antibiotic resistance testing

"STAR is a very easy to use test, with a really short handling time, and results are reliable and robust."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
more sensitive than the other methods
Rating: 5.0

  • Application Area:In Vitro Diagnostics

"This test is very easy to use, and rapid...and faster and more sensitive than the other methods"

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Easy to use.
Rating: 5.0

  • Application Area:In Vitro Diagnostics

"The kit is very easy to use, short handling time, very fast results."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: ASST di Sondrio, Valtellina e Alto Lario



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Very innovative.
Rating: 5.0

  • Application Area:In Vitro Diagnostics

"Very innovative test, reliable and robust, finally mass spectrometry arrived in antibiotic resistance field."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Very fast and sensitive method, perfectly suitable for any kind of lab needs.
Rating: 5.0

  • Application Area:Carbapenemase testing

"Very fast and sensitive method, perfectly suitable for any kind of lab needs."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit


  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Very fast, sensitive and specific method, and very robust and reliable.
Rating: 5.0

  • Application Area:Activity testing

"Very fast, sensitive and specific method, and very robust and reliable."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Easy to use and fast.
Rating: 5.0

  • Application Area:Carbapenemase activity detection

"Very nice test. I have been working in bacteriology for a short time, but I found it easy to use and fast."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Fast and easy to use test! Great for us technicians!
Rating: 5.0

  • Application Area:Detection of carbapenemase activity

"Absolutely fast and easy to use test! Great for us technicians!"

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University Hospital of Bologna - Sant'Orsola-Malpighi



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
STAR is a great test, easy to use, rapid and with great results.
Rating: 5.0

  • Application Area: Detection of carbapenemase activity

"STAR is a great test, easy to use, rapid and with great results."

Review date: 25 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Advanced Reviewer

  • Member since: 2017

  • Organization: Erlanger



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
An excellent kit to measure carbapenemase activity
Rating: 5.0

  • Application Area:Analyze carbapenemase activity

"This is an astonishing achievement. You can now get your organism identification and carbapenemase activity during the same run on the Maldi-tof. It is a very important step for antimicrobial stewardship as it is a crucial piece of data in patient treatment protocol. If the process were less time consuming it would be the BEST OF THE BEST. But, with staffing situations throughout the nation, it is a difficult process to add into workflows."

Review date: 24 Jul 2018 | MBT STAR®-Carba IVD Kit
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: The University of Akron



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Efficient and reliable detection kit.
Rating: 5.0

  • Application Area:Rapid detection of enzyme activity

"Being able to detect drug resistance with a MALDI-TOF-MS system (one of the most efficient and reliable mass spectrometers) is visionary."

Review date: 24 Jul 2018 | MBT STAR®-Carba IVD Kit

The first IVD certified mass spectrometric resistance detection assay

The MBT STAR-Carba IVD Kit (STAR – Selective Testing of Antibiotic Resistance) in conjunction with the MBT STAR-BL IVD software allows rapid microorganism identification and detection of carbapenemase activity in one workflow. This is the first mass spectrometric resistance detection assay expanding the application of the MALDI Biotyper MALDI-TOF mass spectrometry system in clinical microbiology beyond the identification of microorganisms.

Antimicrobial resistance – a major health care threat

Unnecessary prescription of antibiotics, treatment of diseases with broad-spectrum antibiotics and the excessive use of antibiotics in agriculture lead to the emergence of multi-resistant bacteria. Only a few last resort antibiotics are left of which carbapenems are of highest importance. These drugs can be deactivated by bacterial carbapenemase enzymes. To avoid their further spread in hospitals, fast and cost-effective methods for detection of bacteria with active carbapenemases are in high demand.

The MBT STAR-Carba Assay principle

The Kit utilizes Imipenem as the benchmark carbapenem antibiotic. Bacteria from overnight cultures or positive blood cultures are incubated in an Imipenem solution. Bacteria with active carbapenemase will inactivate Imipenem by hydrolysation of the ß-lactam ring, which is associated with a mass shift.

A fast and simple workflow

In assays with bacteria without active carbapenemase only peaks corresponding to the intact antibiotic will be present in the mass spectrum. In assays with bacteria with active carbapenemase, peaks of the intact antibiotic will decrease. The intensity ratio of hydrolysed to intact antibiotic signals indicates the level of carbapenemase activity. 
The MBT STAR-BL IVD Software Module monitors this activity on acquired mass spectra of aliquots of the co-incubation solution (incubation for 30/60 minutes) by automatic calculation of the intact Imipenem intensity and corresponding ratio hydrolysed / non-hydrolysed. Results are normalized to signal intensities from positive and negative control strains and displayed as a color-coded plot as shown below.

What is the MBT STAR-Carba Assay good for?

The MBT STAR-Carba Assay is designed for rapid detection of prevalent Class A, B or D carbapenemase activity in Gram-negative Enterobacteriaceae, Pseudomonas spp. and Acinetobacter spp. It can be used for microorganisms derived from culture plates and optionally for microorganisms isolated from positive blood cultures after isolation of cells using the MBT Sepsityper IVD Kit. The assay allows to rapidly identify bacteria and their carbapenemase activity on the MALDI Biotyper IVD platform in one workflow.

Product Overview

MBT STAR<sup>®</sup>-Carba IVD Kit by Bruker Daltonics product image

MBT STAR®-Carba IVD Kit

Manufacturer Bruker Daltonics

5.0 / 5.0 | 16 reviews