HDX Solution Providing Fast, Automated, Reliable, Quantitative Structural Insights
The Bruker HDX Solution combines the LEAP HDx PAL, with the market-leading Bruker maXis II ETD and state of the art software from Sierra Analytics (HDExaminer) for data analysis. The industry-leading ETD capabilities of Bruker’s maXis II ETD UHR-QTOF offers unparalleled sequence coverage for middle-down and top-down studies while maintaining access to your existing peptide mapping workflows. However, the evolution of HDX-MS from bottom-up strategies based upon pepsin-digestion toward middle-down and top-down studies utilizing the power of ETD fragmentation has the potential to revolutionize the way conformational studies are performed.
The Bruker HDX Solution tool kit delivers automated and reliable HDX-MS workflows with correct monoisotopic accurate-mass readout to fully explore quantitative results from H/D ratios. This enables structural insights about biomolecules to be accessed reliably and with greater certainty and confidence.