Dianthus Pico for challenging affinity screening by NanoTemper Technologies

Dianthus is a plate-based, microfluidics-free affinity screening platform that measures under controlled equilibrium conditions without the need for surface immobilization. The best option if you want the capability of screening binding events with both millimolar and picomolar affinities. Dianthus comes with two different biophysical modalities - Spectral Shift and TRIC - so you succeed at measuring all types of challenging interactions.

Dianthus excels at tackling demanding affinity screening applications where immobilization-dependent techniques like SPR, and sample-consuming ITC struggle. With Dianthus, you have an opportunity to keep your project moving forward when your hit identification or lead optimization involves any of these molecules:

• Ternary complexes, like the ones formed by PROTACs and molecular glues
• Intrinsically disordered proteins
• Fragment libraries

Here’s what makes Dianthus the perfect choice for challenging affinity screening campaigns:

• High signal-to-noise ratio: Reliable affinity measurements
• High sensitivity: Detect more hits with the same platform
• Mass independence: Measure binding with small molecules
• Broad range of affinity screenings: From picomolar to millimolar for detection of strong and weak binders
• In-depth understanding of sample quality: Differentiate between binding and aggregation

Researchers working with challenging targets suchs as PROTACs, IDPs and fragment libraries, add Dianthus Pico to their workflow as it offers them high-quality data that removes any uncertainty about their hits — so they can trust their data and their decision-making.

Dianthus Pico is ready when you want to automate your affinity screening campaigns for hours of uninterrupted and unattended operation. Its 384-well microplate format makes it compatible with many automated solutions. The best part is you won’t be slowed down by regular maintenance.