Corning® Gentest™ MRP/BCRP Vesicle Assay Kit by Corning Life Sciences

Manufacturer Corning Life Sciences  |   Model: 459010  |  Available in North America, Western Europe, Asia, Eastern Europe, Middle East, Africa
The assay kit provides reagents necessary to perform vesicle uptake assays for MRP and BCRP vesicles, sufficient for up to 200 assays and accommodates 4 vials of vesicles following recommended protocol.MRP/BCRP Vesicle Assay Kit allows for characterizing the substrates or inhibitors of MRP/BCRP transporters. The assay measures the cumulative uptake of test compounds in the inside-out MRP or BCRP vesicle transporters to directly determine the substrates or inhibitors of these transporters. This i... Read more


Corning® Gentest™ MRP/BCRP Vesicle Assay Kit by Corning Life Sciences product image
Corning® Gentest™ MRP/BCRP Vesicle Assay Kit
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The assay kit provides reagents necessary to perform vesicle uptake assays for MRP and BCRP vesicles, sufficient for up to 200 assays and accommodates 4 vials of vesicles following recommended protocol.

MRP/BCRP Vesicle Assay Kit allows for characterizing the substrates or inhibitors of MRP/BCRP transporters. The assay measures the cumulative uptake of test compounds in the inside-out MRP or BCRP vesicle transporters to directly determine the substrates or inhibitors of these transporters. This is done using radioisotope-labeled compounds or fluorescence compounds.

Features/Benefits:

  • One kit and one simple protocol for all human and animal MRP/BCRP vesicle studies
  • Excellent alternative to radioactive readout using included CDCF fluorescent substrate for MRP2/MRP3 transporters
  • Time-saving by eliminating reagent preparation steps
  • Robust and stable reagents, accommodating up to six freeze-thaw cycles
  • Supports FDA-and EMA-recommended BCRP and MRP vesicle studies

    Intended Use:

  • Substrate Uptake assays with ABC transporter Vesicle products, including: #453455, 453450, #453452, #453510, #453523, #453271, #453345, #453252, #453500

Kit includes:

  • Assay Buffer
  • 10X Wash Buffer
  • 200 mM ATP
  • 200 mM AMP
  • 300 mM GSH
  • MPR3 Substrate
  • BCRP Substrate
  • MRP2/MPR3 Fluorescent Substrate
  • MRP1/MRP2 Substrate

  • ABC transporter vesicle products are not included in the kit.

For Customers in California only: WARNING Please refer to Safety Data Sheet (SDS) Section 15 or Letter in Lieu for more information regarding California Proposition 65.

Product Overview

Corning® Gentest™ MRP/BCRP Vesicle Assay Kit by Corning Life Sciences product image

Corning® Gentest™ MRP/BCRP Vesicle Assay Kit

Manufacturer Corning Life Sciences  |  Available in North America, Western Europe, Asia, Eastern Europe, Middle East, Africa

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