11BHSD2 Mouse Model by Charles River Laboratories

The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes. Model Properties: Coat Color: Black Ideal For: Cardiac hypertrophy, heart failure Strain Code: 510 HE, 511 HO, 512 WT, This model is cryopreserved.


11BHSD2 Mouse Model by Charles River Laboratories product image
11BHSD2 Mouse Model

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The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes.

Model Properties:

  • Coat Color: Black
  • Ideal For: Cardiac hypertrophy, heart failure
  • Strain Code: 510 HE, 511 HO, 512 WT, This model is cryopreserved.