11BHSD2 Mouse Model by Charles River Laboratories
The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes.
Coat Color: Black
Ideal For: Cardiac hypertrophy, heart failure
Strain Code: 510 HE, 511 HO, 512 WT, This model is cryopreserved.