SupelMIP® SPE - Patulin
The SupelMIP SPE line consist s of highly cross-linked polymers that are engineered to extract a single analyte of interest or a class of structurally related analytes with an extremely high degree of selectivity. This is possible because selectivity is introduced during MIP synthesis in which a template molecule, designed to mimic the analyte, guides the formation of specific cavities or imprints that are sterically and chem…
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The SupelMIP SPE line consist s of highly cross-linked polymers that are engineered to extract a single analyte of interest or a class of structurally related analytes with an extremely high degree of selectivity.
This is possible because selectivity is introduced during MIP synthesis in which a template molecule, designed to mimic the analyte, guides the formation of specific cavities or imprints that are sterically and chemically complementary to the analyte(s) of interest.
By careful design of the imprinting site, either by molecular modeling, experimental design, or screening methods, the binding cavities can be engineered to offer multiple interaction points with the analyte(s) of interest. This leads to a stronger interaction between the solid-phase and the analyte(s). As a consequence, harsher wash conditions can be tolerated during SPE methodology resulting in cleaner extracts. Because extraction selectivity is significantly improved, lower background is observed allowing analysts to achieve lower limits of detection.
Features & Benefits:
- Highly selective SPE for trace analysis in complex matrices
- Achieve lower detection limits
- Significant time and cost savings
- Improved MS-compatibility
Selective Extraction and Low Level Quantification of the Mycotoxin Patulin from Organic Apple Puree
Patulin is a mycotoxin that commonly infects apples used to produce juice and other apple products. Exposure to patulin may negatively impact human health so it is regulated in many countries including the United States and European Union member states. A method utilizing SupelMIP® SPE- Patulin cartridges and a Titan™ C18 UHPLC column with UV detection was developed to successfully demonstrate the extraction, detection, and quantification of patulin at low concentrations in organic apple puree.
The Extraction of Amphetamine and Related Drugs using Molecularly Imprinted Polymer SPE
This application note describes a simple, fast and class selective method for trace extraction of amphetamine related drugs from urine samples using a molecularly imprinted polymer SPE (SupelMIP™), specifically designed for selective extraction of amphetamine related drugs. The SupelMIP technique is also compared against a recently published extraction technique using a conventional hydrophilic polymer SPE phase.
Selective Extraction and Cleanup of Patulin Mycotoxin from Apple Juice Samples
This application note describes the use of Molecularly Imprinted Polymer SPE and HPLC‑UV for the cleanup and analysis of Patulin mycotoxin in apple juice.
