Metal Scavengers and Organic Scavengers – SiliaMetS® & SiliaBond®
SiliCycle is a pioneer in metal and organic scavenging solutions. We have nearly two decades of know-how in silica-grafting and scavenging technologies, and the broadest portfolio of scavengers.The removal of post-reaction residues has become a major issue in the pharmaceutical industry, among others. Purification of APIs by traditional methods (chromatography, activated carbon, distillation, etc.) often leads to problems such…
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SiliCycle is a pioneer in metal and organic scavenging solutions. We have nearly two decades of know-how in silica-grafting and scavenging technologies, and the broadest portfolio of scavengers.
The removal of post-reaction residues has become a major issue in the pharmaceutical industry, among others. Purification of APIs by traditional methods (chromatography, activated carbon, distillation, etc.) often leads to problems such as high costs, time loss, low efficiency and reduced final yields.
To overcome these drawbacks, SiliCycle has developed two families of scavengers that have significantly improved how chemists purify APIs: SiliaMetS Metal Scavengers and SiliaBond Organic Scavengers. The backbone of all those products is SiliCycle SiliaFlash® F60 (40-63 µm, 60 Å) which provides superior performance for all types of applications, due to its narrow particle size distribution and exceptional purity. What's more, we can provide different particle sizes or pore diameters on a custom basis.
SiliCycle’s quality is famous and recognized, proven by countless applications and patents in literature. With our strong, extensive and confidential team of experts, your projects are in the best possible hands.
SiliaMetS, your Metal Scavenging Final Solution
- Highly selective and cost-effective alternative for metal removal
- Expert team to help you consider every parameter: metal catalyst, solvent, residual reagent, by-products, structure of the API, temperature…
- Kits available for initial screenings.
- No leaching (no contamination).
- High selectivity (total recovery of the API).
- Wide range of metal species scavenged.
- Fast kinetics even at r.t. for maximal time-savings.
- Excellent stability (thermally and mechanically).
- New technologies compatibility (flow chemistry, microwave).
- Available both in Bulk or Fixed Bed (SPE or Flash cartridges) Mode.
SiliaBond, your Best Bet for Removing Unwanted Organic Impurities and PGIs:
- Designed to react and bind a very large array of excess reagents and by-products
- High selectivity (total recovery of the API)
- Kits available for initial screenings
- Great for purification of potentially genotoxic impurities (PGI)
- Eliminates tedious post-reaction purifications
- Available both in Bulk for direct trapping or in SPE cartridges for the so-called “catch-and release” method
- Electrophile and Nucleophile Scavengers available
- Large team of experts always available to help you develop the best experimental conditions
New Silia<i>Bond</i>® Coupling Reagents to Expedite Amide and Ester Synthesis
This poster demonstrates that amides and esters can be successfully prepared in a timely manner using various SiliaBond Coupling Reagents.
Silia<i>MetS</i>® Metal Scavengers: An Efficient Tool to Remove Metal Residues from APIs and Their Intermediates
This poster shows that SiliaMetS Metal Scavengers can be used as an efficient method to remove palladium residues from reaction mixtures containing APIs or their intermediates.
Silia<i>MetS</i>® Cysteine: A New Highly Efficient Silica-Bound Scavenger for Heavy Metals
The removal of metal residues from post reaction mixtures has become a major issue for the pharmaceutical industry. This poster highlights some applications of Si-Cysteine as a metal scavenger in synthesis. Results show that SiliaMetS Cysteine can be used as an efficient method to remove tin residues from organic mixtures.
Silia<i>MetS</i>® Metal Scavengers: An Efficient Tool to Remove Metal Residues from Small to Large Scale APIs Synthesis
In this poster, the synthesis of an important key synthetic intermediate, involving metal-mediated reactions, most specifically Suzuki-Miyaura couplings, is presented and the scavenging efficiency of SiliaMetS Metal Scavengers is highlighted in both bulk and SiliaSep Flash Cartridges formats.
Efficient Removal of Osmium-based Catalysts Using Silia<i>MetS</i>® Metal Scavengers
In this poster, three organic reactions involving osmium reactants are described, and the metal scavenging efficiency of SiliaMetS Metal Scavengers is highlighted.
Flow Chemistry Using Silica-Based Silia<i>MetS</i> Metal Scavengers, Silia<i>Bond</i> Functionalized Silica Gels and Silia<i>Cat</i> Heterogeneous Catalysts
SiliCycle® has developed innovative silica-based metal scavengers (SiliaMetS), reagents (SiliaBond), and catalysts (SiliaCat), that can be successfully used in flow chemistry. SiliaMetS functionalized silica gels, SiliaBond reagents, and SiliaCat heterogeneous catalysts are great alternatives over competitive products often used in flow chemistry. Results of coupling and hydrogenation reactions using SiliaCat catalysts are presented in this poster. Metal removal using SiliaMetS Thiol and other reactions using SiliaBond reagents are also presented.
