Imaris Software

Dr. Danielle Beckman, Project Scientist at the California National Primate Research Center, will introduce how they apply high-resolution confocal microscopy to help the development of different primate models for neurological disorders. She will also show how acquisition of z-stack images in association with 3D reconstruction performed at Imaris helps them investigate neurodegeneration and neuroinflammation in different disease models.

Key learning objectives

• Microglia morphology: Learn how to create and edit 3D surfaces to analyse microglia volume and interaction with other cell types. Understand what the indicators are for microglia activation and neuroinflammation.
• Viral infections: Discover how to identify and quantify different markers for viral infection.
• Neuronal death: Understand how to detect neurons dying using multilabel confocal microscopy, especially in combination with neuroinflammatory markers

Who should attend?

Both new and experienced Imaris users interested in accelerating microscopy projects. The research is relevant across life science projects where visualization and analysis is required.

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

Aquaporin (AQP) water channels facilitate water diffusion across lipid bilayers following an osmotic gradient. AQPs are especially important in renal water reabsorption. AQP2 in the renal collecting duct mediates fine-tuning of urine volume in response to the antidiuretic hormone arginine vasopressin (AVP).

AVP mediates plasma membrane insertion of AQP2 from an intracellular reservoir of AQP2 containing vesicles, which instantly increases water reabsorption and urine concentration. The vesicle population cannot be resolved via conventional fluorescent microscopy, therefore detailed information regarding the AQP2 vesicular population is still lacking.

Expansion microscopy (ExM) addresses challenges in resolving vesicle populations. Newly established 4.5x ExM can increase resolution to 60–70 nm. In this webinar, Dr. Lene Niemann Nejsum, Professor of Epithelial Physiology and Pathophysiology at Aarhus University, will present results showing that 4.5 ExM is an ideal approach to obtain detailed information regarding the AQP2 vesicle population. Using 4.5x ExM, spinning disk microscopy and image processing, Dr. Nejsum and her team detected AQP2 vesicles/endosomes. Using different markers of the endosomal system, they obtained detailed information of the cellular AQP2 shuttling itinerary.

Key learning objectives

• Understand how Aquaporin mediated water transport across lipid bilayers
• Gain insight into Studies of intracellular vesicles using Expansion Microscopy
• Learn more about the Use of Andor BC43 with Deconvolution for ExM

Who should attend?

• Both new and experienced Imaris and BC43 users interested in accelerating microscopy projects. The research is relevant across life science projects where visualizsation and analysis is required.

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

Andor is excited to announce the expansion of its Benchtop Microscope range, adding application and budget-based flexibility to the original BC43 Benchtop Confocal. These Benchtop Microscopes now start with motorized multi-dimensional widefield fluorescence imaging and extend into super-resolution range.

Dr. Geraint Wilde, business manager – life science microscopy, Oxford Instrument Andor, will introduce new products and the different imaging modalities of widefield, confocal, and super-resolution fluorescence microscopy. The biological models and typical experiments those modalities can be optimally used with will also be discussed.

Additionally, Dr. Wilde will cover how the modular design means Andor’s latest products can be upgraded in the field over time as your research needs change.

Key learning objectives

• Learn about the new extended BC43 product range
• Gain insight into different modes (widefield, confocal, and super-resolution) and the sample types they are applicable to
• Understand the achievable multiple scales of imaging

Who should attend?

Both new and experienced BC43 users interested in accelerating microscopy projects. The research is relevant across life science projects where visualization is required.

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes

Andor's microscopy solutions provide best-in-class performance within a modular architecture and can cater for a wide number of application fields in the world of cell biology. This video shows examples of a number of applications for which Andor’s range of cell biology toolkits can be used.

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