HLA Panel & MHC Panel
TargetSeq® Human HLA Panel and TargetSeq® Human MHC Panel are HLA gene detection products based on TargetSeq® hybridization capture technology developed by iGeneTech. These panels are highly efficient in capturing the polymorphic region and combined with NGS technology to achieve high-precision typing of the HLA gene at 6 sites, and can be widely used in the field of immunology research.
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TargetSeq® Human HLA Panel is designed to detect 6 genes related to human leukocyte antigens (HLA) including the full-length sequences of HLA class I molecules A, B, and C genes and the full exon sequences of HLA class II molecules DRB1, DQB1, and DPB1 genes. Based on typing analysis, this panel can be applied to transplant mapping, immune disease research, drug allergy, and other directions.
HLA 15 Genes Panel V2 referenced the Expert Consensus on Standardized Construction of HLA Genotyping Technical Platform and Its Clinical Application. It has targetedly expanded to genotyping detection of 15 genes commonly used in clinical applications. Specifically, probe design covers the full-length sequences of HLA-A, B, and C genes, as well as the full exonic sequences of HLA-DRB1, DQB1, DPB1, DRB3/4/5, DQA1, DPA1, DOA, DOB, DMA, and DMB genes, enabling 6-digit high-resolution accurate genotyping.
Advantages
- High resolution, enabling 6 sites of high-precision genotyping.
- Rigorous design, with probes achieving high coverage of the target region.
- Flexible custom, with the possibility of customizing customer-specific HLA typing products based on actual needs.
Performance
HLA Panel for 6 Sites High-Precision Genotyping
Nearly 100 samples were used for library construction by IGT® Enzyme Plus Library Prep Kit, and TargetSeq® Human HLA Panel was for target enrichment. After sequencing with PE150, HLA-HD analysis software was used for typing. The results showed up to 100% consistancy with the HLA typing results of the conventional PCR SBT method, allowing high-precision genotyping at 6 sites. The figure on the right shows an example of HLA 6 sites high-precision typing results.
Genotyping Validation Results of HLA 15 Genes Panel V2
Multi-gene genotyping validation was conducted using the HLA standard from Nanjing Kebai Biotechnology (CBPQ0007). This Panel can accurately detect the genotyping results of the corresponding standard, with completely consistent genotyping outcomes.
