3M™ Harvest RC Chromatographic Clarifier
The 3M™ Harvest RC Chromatographic Clarifier is a single stage single-use chromatographic clarification solution designed as an efficient option for harvesting and clarification of modern cell cultures. Clarification using 3M™ Harvest RC Chromatographic Clarifier may provide many benefits including fewer processing steps, higher yield and lower production time and costs.
3M™ Harvest RC Chromatographic Clarifier family of products
3M™ Harvest RC Chromatographic Clarifier process train
3M™ Harvest RC Chromatographic Clarifier platform infographic
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3M™ Harvest RC Chromatographic Clarifier encapsulates innovative synthetic fibrous anion exchange (AEX) chromatography media and a 0.2 μm polyether sulfone (PES) membrane. This enables a single-stage clarification process of low to high-density cell culture (>40 million cells per mL) with high recovery and high separation fidelity of soluble and insoluble impurities.
Cells are bound inside the media by electrostatic charge interaction with the AEX chromatographic fibers. This results in the efficient retention of large and small particulates without developing a surface cake layer. The media can also remove soluble impurities which results in cleaner effluent than centrifugation or depth filtration.
Key features and benefits:
- Simplification of high cell density cell culture fluid clarification unit operations
- Optimized for high density CHO cell cultures (5 - 8% packed cell volume, PCV)
- Replacement of primary, secondary, and guard membrane clarification stages
- Typical product recoveries of >95% (capsules)
- Synthetic chromatographic harvest media with chemically defined extractables
- Predictable scaling from discovery to manufacturing
The future of clarification processes
Dr. Alexei Voloshin, Global Head of Bioprocess Science at Solventum, discusses the need for advanced clarification processes in product development. He introduces the 3M™ Harvest RC Chromatographic Clarifier and 3M™ Harvest RC Centrate Chromatographic Clarifier, designed to separate soluble and insoluble impurities effectively. The 3M™ Harvest RC Chromatographic Clarifier platform also enhances process development and addresses challenges faced by biologics producers. Elliott Zell, Global New Product Marketing Manager at Solventum, emphasizes the importance of understanding customer needs and the speed of bringing new products to market.
Clarify CHO cell cultures in a single step with 3M™ Harvest RC Chromatographic Clarifier platform
Kuan-Yin Lin, Product Development Specialist at Solventum, describes the features of the 3M™ Harvest RC Chromatographic Clarifier and the 3M™ Harvest RC Centrate Chromatographic Clarifier. This platform of chromatographic solutions enables the clarification of CHO cell cultures and centrates in a single step. These technologies provide a new dimension of clarification capability by incorporating a functionalized anion exchange media to improve separation fidelity. Hear how Solventum is reinventing CHO clarification and improving speed to market with its chromatographic clarification platform approach.
Enhancing productivity and sustainability in bioprocessing
Dr. Alexei Voloshin, Global Head of Bioprocess Science at Solventum, discusses the critical role of innovation in bioprocessing. He highlights the industry's need for increased productivity and the importance of advanced separation technologies. By retooling old manufacturing processes and developing new strategies, the future of bioprocessing aims to be more efficient and sustainable, using fewer resources while improving access to medicines in resource-limited areas.
Simplify recombinant protein harvest and clarification processes with a unified solution platform
Recombinant protein harvest and clarification unit operations are increasingly challenged with higher cell densities, newer and more complex therapeutic modalities, and the need to rapidly scale up and down. The 3M™ Harvest RC Chromatographic Clarifier platform is a scalable clarification platform that offers consistent and comparable clarified fluid quality across the platform. Discover how the platform achieves enhanced product recovery to >95%, and superior impurity removal to <500 ppb DNA.
