The next generation of preclinical models

From target validation to translational decision-making, the limitations of traditional preclinical models continue to challenge the predictability of drug discovery. As the industry seeks more human-relevant systems, next-generation models such as organoids and organ-chips are reshaping how researchers study disease biology, assess safety, and evaluate therapeutic efficacy earlier and more accurately.

In this SelectScience^® editorial feature, explore a curated collection of expert articles, technologies, and videos highlighting advances in preclinical modeling. From complex 3D organoid systems to microphysiological organ-chip platforms, these resources showcase approaches designed to better capture human physiology and improve translational confidence. Whether you are refining disease models, reducing late-stage attrition, or strengthening the bridge between preclinical and clinical research, this collection provides both strategic insight and practical guidance to support more predictive, physiologically relevant drug discovery.