Tosoh Bioscience - Separations Products & Reviews

“Allround“ SEC-columns for initial analysis of unknown samples

EcoSEC Elite and EcoSEC HT GPC/SEC Systems enable efficient polymer characterization

TSKgel GPC columns for organic-soluble polymers are packed with spherical particles composed of polystyrene crosslinked with divinylbenzene (PS-DVB)

TOYOPEARL AF-rProtein A HC-650F is designed for high capacity purification of antibodies

TOYOPEARL GigaCap® Series offers highest capacity for ion exchange purification steps

Ca++Pure-HA is a hydroxyapatite resin used in the chromatographic separation of biomolecules.

TSKgel FcR-IIIA-NPR  affinity columns for direct analysis of mAb activity.

TSKgel Protein A-5PW affinity columns for direct analysis of mAb titer. 

TOYOPEARL NH2-750F offers a high binding capacity across a range of pH values and conductivities

TSKgel SuperQ-5PW is especially suited for industrial purification of oligonucleotides

TSKgel Butyl-NPR hydrophobic interaction columns for analysis of antibody-drug conjugates (ADCs) and as an orthogonal method to analyze protein aggregation, oxidation and deamidations.

The TSKgel DNA-NPR weak anion exchange column is designed to analyze nucleic acids. It routinely separates plasmid isoforms, PCR products and oligonucleotides.

TOYOPEARL HW-50S resin is a hydroxylated methacrylic polymer for size exclusion chromatography.

TSKgel Amide-80 and TSKgel NH2-100 HILIC columns from Tosoh Bioscience are first class columns when it comes to separations of hydrophilic compounds like peptides, carbohydrates, polar natural substances, amino acids, oligonucleotides, organic polar acids and bases, even proteins.

HPLC column

Widely considered the premium columns for analyzing biopolymers by GFC, TSKgel G2000SWXL, 5 μm columns are an excellent choice for small proteins and peptide separations.

The TSKgel Alpha-4000 column is packed with rigid, porous polymer beads which show minimal shrinkage or swelling in polar organic solvents (methanol, acetonitrile, DMSO, isopropanol, THF, and HFIP). This column is stable in a wide variety of organic solvents at concentrations up to 100%.

TOYOPEARL HW-55S resin is a hydroxylated methacrylic polymer for size exclusion chromatography

Media, Process Resins; For Hydrophobic Interaction Chromatography; Tosoh Toyopearl Ether-650M, 65 micrometer; Matrix: Polymer; Container Size: 100mL

The TSKgel OligoDNA RP and TSKgel TMS-250 columns incorporate 5 μm or 10 μm spherical porous silica with 250Å pores to allow unhindered access by large oligonucleotides and proteins respectively.

TSKgel STAT columns were designed to increase throughput for high efficiency separations of biomolecules. The nonporous, hydrophilic base material provides superior performance at reduced analysis time.

TSKgel SW-type columns for size exclusion/gel filtration analysis of antibodies and other proteins are silica-based. A hydrophilic diol-type bonded phase shields the silica surface from interacting with protein samples.

The LenS3 MALS detector offers a revolutionary approach for the measurement of molecular weight (MW) and radius of gyration (Rg) of synthetic polymers, polysaccharides, proteins, and biopolymers. A novel optical design, a unique cell-block assembly, and a new calculation methodology make the LenS3 MALS detector the first groundbreaking innovation in the light scattering technology arena in decades!

TSKgel Phenyl-3PW (20) process resin provides a novel solution for the purification of oligonucleotides. This resin is capable of cleaving DMT protective groups on-column in order to streamline downstream bioprocessing of complex oligo species.

TOYOPEARL Super A is a novel, robust protein A resin designed to efficiently purify mAbs and other antibody species like ADCs and bispecifics. This resin offers high alkaline stability, exceptional dynamic binding capacity, and a polymer base bead able to withstand high linear velocities.