Sartorius Group Drug discovery > Basic Research Products & Reviews

High-performance label-free, real-time biomolecular analysis

Label-Free Analysis in a drop.

High throughput label-free performance.

Unrivaled performance with 2 minutes to quantitate 96 samples or 15 minutes to run 384 binding kinetics.

Superior quantitation and kinetics performance with increased assay flexibility and cost efficiency.

For determination of antibody concentration  

High performance BLI for label-free kinetics without compromise.

Impurity testing made faster and easier than ever.

Completely hands-off, walk-away HCP analysis in 1 hour.

The Octet® GlyM Kit enables high-throughput mannose content screening in crude cell culture samples during early clone selection stages in the CLD process. When combined with titer analysis, it expedites the selection of the top performing cell lines producing proteins with the most favorable glycan (mannose) profile. funnel through samples that are high producers and have desirable sialic acid content.

High-throughput sialylation screening for expediting the clone selection process

Affordable and Flexible Biologics Development 

The Incucyte® AI Cell Health Analysis Software Module is an all-in-one analysis tool that segments cells and classifies them as live or dead. It allows users to perform cell health analyses without the need for fluorescent labels, generating accurate and objective data with reduced time requirements and cost. 

Incucyte® Proliferation Assays for Live-Cell Analysis

Monitor adherent cell morphology changes objectively to determine live/dead cell counts or classify cells based on morphology via label-free multivariate analysis

Octet® FAB2G biosensors come pre-immobilized with a high-affinity ligand that is specific for the CH1 region of Human IgG. The anti-human CH1 ligand has no recognition towards free light chains or cross-reactivity with murine or bovine IgG. This high level of specificity enables direct analysis of IgG or Fab analytes directly from complex samples such as cell culture supernatants, lysates, or partially purified samples, offer…

Octet® AHQ biosensors provide a rapid method for precise quantitation of human immunoglobulins from crude lysates and cell culture supernatants. Factory immobilization of an anti-human IgG antibody onto the biosensor surface enables direct detection of human IgG analytes with minimal sample handling and facilitates sample quantitation from cell culture screening through downstream purification development.

Octet® ProA biosensors are coated with Protein A and enable rapid antibody quantitation from crude lysates, cell culture supernatants and complex matrices.

Octet® AMQ biosensors provide a rapid method for precise quantitation of murine immunoglobulins from crude lysates and cell culture supernatants. 

Octet® APS Biosensors are coated with aminopropylsilane and provide a convenient method for hydrophobic based immobilization of most protein analytes for assaying the kinetic profile of protein-protein interactions. 

Octet® SSA (Super Streptavidin) Biosensors offer the highest sensitivity for the demands of small molecule kinetic experiments.

Octet® Anti-Human Fc Capture (AHC) Biosensors are designed for kinetic characterization of interactions between human Fc-containing proteins and target analytes. Octet® AHC Biosensors are offered in a tray format. Each tray contains 96 biosensors. Larger orders include discounts.

Octet® Anti-Mouse Fc Capture (AMC) Biosensors are designed for kinetic characterization of interactions between mouse Fc-containing proteins and target analytes. Octet® AMC Biosensors are offered in a tray format. Each tray contains 96 biosensors.

The Octet® Amine Reactive 2nd Generation (AR2G) Biosensors are designed for EDC/Sulfo-NHS based immobilization of primary amine containing biomolecules and kinetic characterization of their interactions with target analytes. The use of the AR2G Biosensors requires the Amine Coupling Second-Generation Reagent Kit (AR2G Kit, Item no.: 18-5095). Octet® AR2G Biosensors are offered in a tray format. Each tray contains 96 biosensor…

The polyhistidine protein tag (His-tag), commonly engineered into proteins during cloning, can be used to facilitate recombinant protein purification and detection by exploiting the chelating properties of histidine to an immobilized metal. The Octet® HIS1K Biosensors consist of high affinity, high specificity Penta-His antibody pre-immobilized on a fiber optic biosensor. In conjunction with the Octet® systems, the Octet® HIS…