Thermo Scientific™ Orbitrap Exploris™ 120 mass spectrometer

Over 9,000 known per- and polyfluoroalkyl substances (PFAS), with more being actively discovered, dictate the need for a comprehensive non-targeted analysis of PFAS by high-resolution accurate mass (HRAM). Thermo Fisher Scientific presents a fusion of the most prominent untargeted PFAS analysis techniques leveraged within a single workflow using Compound Discoverer software as a turnkey solution. Discover how a range of onboard visualization tools alongside other innovative features enables a simplified approach for analyzing this concerning class of small molecules.

Innovation in analytical technologies can enable anti-doping authorities and testing laboratories to stay ahead of evolving doping techniques and illicit substances to ensure a trustworthy and clean sporting environment. Continued enhancement of such technologies, including heightened sensitivity and accelerated processing speeds, plays a pivotal role in shaping the trajectory of future anti-doping endeavors.

In this eBook, we provide information and solutions to ensure you are up to date with the latest advancements in anti-doping technologies. The aim of this guide is to provide you with the cutting-edge tools and methodologies that stand at the forefront of the fight against doping, ensuring a fair and integrity-driven landscape in the world of sports.

Explore the content to:

• Conduct a robust analysis of banned substances in equine plasma
• Utilize an all-in-one LC-MS/MS solution for toxicology
• Stay ahead of regulations for steroid analysis in urine
• Gain unstoppable confidence with user-centric GC-MS/MS systems
• Solve the challenges in your analytical testing labs
• Set the new standard in productivity
• Couple GC-IRMS with quadrupole GC/MS for confirmatory analysis
• Discover a novel technique for the detection of polar compounds

In this application note from Thermo Fisher Scientific, explore a method for fentanyl screening and semi-quantitation in urine for all 212 fentanyl analog compounds contained in the Fentanyl Analog Screening (FAS) Kit and Emergent Panels. Sample preparation includes simple 20× dilution in water, quantitation by full high-resolution accurate mass (HRAM) MS scan, and confident confirmation by retention time, accurate m/z, isotope pattern matching to calculated theoretical isotope pattern, and matching experimentally collected MS2 spectra to an in-house MS2 spectral library.

In this application note from Thermo Fisher Scientific, explore a method for quantitation of the Traceable Opioid Material™ (TOM) kit compounds in urine that includes sample preparation by supported liquid extraction (SLE), quantitation by full scan high-resolution accurate mass (HRAM) data, and confident confirmation by retention time, accurate m/z, isotopic pattern matching and experimental matching of collected MS2 spectra to an in-house MS2 library of 213 fentanyl analog compounds.

In this scientific poster, Thermo Fisher Scientific aims to confirm and quantify 106 drugs frequently tested for in forensic and clinical research labs using liquid chromatography and high-resolution, accurate mass (HRAM) and triple quadrupole mass spectrometry technology. Urine samples spiked with drugs were processed, separated, and detected, achieving successful detection and quantitation at very low concentrations. This method meets the sensitivity requirements for routine laboratories, including those monitoring forensic and sport anti-doping samples.

In this application note, Thermo Fisher Scientific presents a targeted screening and quantitation method for a wide range of drugs of abuse and toxins using the Thermo Scientific™ Tox Explorer™ Collection. This workflow utilizes the high-resolution, accurate-mass Thermo Scientific™ Orbitrap™ Exploris™ 120 mass spectrometer. The method involves screening identified compounds against a comprehensive HRAM MS/MS spectral library and a compound database containing molecular formula, exact mass, retention times, and fragment ions.

Food safety is of paramount importance to public health, and animal products destined for human consumption are closely monitored by global food agencies to ensure that Maximum Residue Limits (MRLs) are not exceeded.

In this veterinary drug residue testing eBook, we consider the Thermo Fisher Scientific suite of LC-MS/MS technologies and their add-ons through a range of case studies demonstrating their use in meat and milk veterinary drug residue testing. We will explore how these analytical methods can tackle specific groups of compounds or high-throughput simultaneous screening of multiple residues, overcoming muscle matrix problems and improving Limits of Quantification (LOQs).

To preserve quality and reduce food wastage during transport, food products are often packaged in materials such as plastics, aluminum cans, or glass. However, the quality and integrity of these materials must be continuously evaluated by suppliers to ensure the composition of food is not changed due to the accumulation of migrant substances.

In this infographic, we explore the growing complexity of food contact material testing within global supply chains, the considerations that come with the increased use of recycled ingredients, legislative insights, and how suppliers can improve their compliance testing whilst supporting the increasing needs of research and development and quality testing departments.

Download the accompanying slides to the SelectScience webinar: Robust metabolic profiling for routine quantitation and confident unknown identification. During this webinar, Amanda Souza, Metabolomics Program Manager, Thermo Fisher Scientific, discusses a targeted profiling workflow for accurate quantitation of knowns and the ability to retro-mine the data to discover unknown biomarkers and how you can build in QA/QC in your metabolomics experiments for high-quality data and high-quality results. Watch the webinar here>>

John Quick from ALS Environmental introduces a method designed using high-resolution mass spectrometry (MS) on the LC Orbitrap™ system for studying 47 PFAS compounds in UK waters. Quick discusses his team's methodology using the Thermo Scientific™ Orbitrap™ Exploris™ 120, presenting an extraction method based on EPA 1633, and achieving limits of detection of <1 ng/L for all compounds with good precision and bias. See how high-resolution MS provides scope for advancement in targeted and untargeted PFAS screening methods.

Discover how Dr. Erika Castrignanò, Principal Analyst at King's College London's Drug Control Centre, employs liquid chromatography and mass spectrometry for sports testing. Explore the principles of wastewater-based epidemiology and its impact on combating doping in elite sports, as well as understanding drug consumption in wider communities.

Professor. Kim Wolff, Director of King's Forensics and Head of the Drug Control Centre at King's College London, specializes in forensic toxicology and anti-doping science. Wolff discusses the overlap between the two fields, emphasizing the need for sensitive methods to detect drugs at major events. Find out how innovations like dried blood spot testing and a new instrument from Thermo Fisher Scientific, helps Wolff’s team differentiate between synthetic and natural steroids used by athletes.

Join Christiaan Barlett, Lab Operations Manager at King's College London's Drug Control Centre, as he discusses athlete biological passports, an innovative system for the detection of blood, steroid, and growth hormone doping, ensuring fair competition in elite-level sporting events like the Olympics. During the Paris 2024 Olympic games, the turnaround time for passport testing changes from 20 days to an astonishing 24 hours, so that cheats can be detected quickly. Bartlett explains how this is possible with the highest possible accuracy.

The quality and integrity of food contact materials must be evaluated by suppliers to meet various regulatory guidelines around the world. Their presence poses a potential risk to consumer health, making accurate and robust detection of these compounds an essential step in protecting your brand reputation.

In this video, learn about the types of compounds that can migrate from food contact materials into foodstuffs, the variables that impact migration rate, considerations for new innovative packaging materials, and discover how chromatography, mass spectrometry, and software solutions can help you confidently quantify and unambiguously identify harmful compounds from food contact materials so you can easily report across targeted and non-targeted analysis of volatiles, semi-volatiles, non-volatiles, and elemental impurities.

In this new eBook, find cutting-edge technologies to solve anti-doping analysis challenges

SelectScience speaks with three leading experts in mycotoxin analysis to discuss the latest developments in this field

Food testing expert, Marco Redaelli, shares his mission to make the world a healthier place, and reveals the technologies helping to deliver more reliable and faster results than ever before