Maestro Z
Live-cell analysis system
Maestro Z system
96-well CytoView-Z plate
Maestro Z family
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Great for easy quantitative data on cell proliferation!
Analyzes Quantitative cell proliferation
We did a Demo on the Maestro Z for applications in Cultured Meat. Specifically we needed a system that was relatively high throughput, efficient, and quantitative without needing end point assays. One of the big hurdles in the cultured meat industry is the cost of media and our company aims to use our technology to create affordable media for growing muscle cells. We needed to test up to hundreds of different formulations as quickly as possible without much labor as a 4 person start up company. The Maestro Z did this wonderfully for us. One thing about the plates is that they do need a coating for cell adhesion which made it difficult to translate to our bioprocess as our bioreactor surfaces are not coated, but we got some interesting data from the machine and how cells interact with our various serum free media.
Review Date: 21 May 2024 | Axion BioSystems
This is a very important instrument in the CGT lab.
Cytotoxicity assay, teer assay
This is very user friendly. Easy to handle once the instrument is installed. Also can check the reaction in real-time. This solves the problem of flow cytometer.
Review Date: 21 Mar 2024 | Axion BioSystems
Good job
cell toxicity assay
It's easy to use in the cell toxicity assay. The results are similar to the CCK-8 assay. However, it need more cells to seed in the plates.
Review Date: 30 Mar 2022 | Axion BioSystems
Great results!
Cancer Immunology
Quantitative data with a convenient mobile app. The Maestro Z provides a quantitative measurement of CAR-T cell-mediated cytotoxicity. The system is very easy to use, and it's powerful to see CAR-T cell killing profiles over time. The number of experiments you can run continuously with majority hands-off time is incredible. The mobile app is also great for making decisions about when to come into the lab when to add effectors, and so on.
Review Date: 13 Dec 2021 | Axion BioSystems
Excellent machine, excellent company.
SARS-CoV-2 Research
We are a lab studying SARS-CoV-2, so we were very pleased with how easy it was to install the Maestro Z system in our BSL3 lab and start collecting data the same day. Setting up experiments is quite straight forward with the plate map editor that allows you to design concentration response curves in a few clicks. This along with the new Maestro Z App that allows tracking of my experiments on my smartphone makes for a very nice user experience. The Maestro Z assay is very sensitive allowing us to detect virus-induced effects within 24 hours after infection, much faster than a plaque assay. We also appreciate that the machine provides kinetic results with very fine resolution allowing us to watch as the infection progresses over time. Finally, the customer support we have received from Axion has been nothing short of exceptional.
Review Date: 31 Aug 2020 | Axion BioSystems
Sensitive data on an easy-to-use system.
Immuno-oncology assays
The Maestro Z was incredibly easy to use, and demonstrated sensitive, real-time measurements of brain cancer cell proliferation and T cell cytotoxicity. The product is easy to set up in the laboratory space due to the convenient size and the independence from needing to place it inside an incubator. The software is very user friendly and allows for monitoring results as they occur as well as simple analysis upon completion.
Review Date: 14 Jan 2020 | Axion BioSystems
User-friendly and powerful platform
Analyze cancer cell proliferation and migration
We found the Maestro Z to be extremely user-friendly with simple, yet powerful software. The setup was also easy and non-disruptive to other work since it does not require any space in the incubators. The system is very sensitive, detecting subtle differences in breast cancer cell migration to provide quantitative data for our work that was not as easily obtained with other methods. This is a great system for easily monitoring cell behavior in real-time.
Review Date: 20 Dec 2019 | Axion BioSystems
Track cell proliferation, viability, morphology, and immune cell-mediated killing with the Maestro Z™. Axion BioSystems Maestro Z platform offers impedance-based cell analysis for real-time, continuous, label-free monitoring of your cells. Continuous data reveals the kinetics of cell-cell interactions and cell-drug responses for better mechanistic understanding without the time- and cost-intensive process of repeating multiple endpoint assays. Now with a smartphone app allowing you to check on your experiment from outside the lab.
KEY FEATURES
- Monitor your experiments from outside the lab — The new Maestro Z App allows you to check in on your cells and experiment to ensure everything is running smoothly while you are away from the lab.
- Precisely control the cell environment — There is no need for an additional cell culture incubator, saving valuable lab space and money. Maestro Z’s smart environmental chamber finely controls temperature and CO₂ while rejecting electrical noise and mechanical vibrations.
- Continuous cell monitoring — 96 simultaneous live recordings from your cells. The Maestro Z system performs noninvasive electrical measurements from the cultured cell population, circumventing the use of dyes/reporters that can perturb your cell model and confound results. Track activity over hours and weeks from the same population of cells label-free and in real time.
- See your cells — Maestro Z’s transparent CytoView-Z™ 96-well plates have a viewing window in each well, allowing for cell visualization and assay multiplexing.
- Start your assay with the push of a button — “One button setup,” means temperature and CO₂ levels automatically adjust on plate docking. Plate usage is logged via an integrated plate barcode scanner for convenient experiment tracking.
- Review your results faster — The Impedance module with AxIS Z™ software provides a simplified approach to the setup, execution, and analysis of experiments.
- Increase throughput with multiple Maestros — Continuously monitor multiple plates automatically and simultaneously with multiple Maestro support. Save space in your lab by controlling multiple Maestro systems using a single computer.
Multiplex your assay: Maestro + Omni™
- Platform cross-compatibility lets you view live-cell imaging alongside real-time, functional data to enhance your analysis.
- Monitor electrode coverage and cell morphology to ensure consistent, quality results.
- Experience no-hassle tracking — the Axion Portal automatically links data via barcode.
SOFTWARE
The Maestro Z system is available with two software modules: Impedance and GxP Impedance. Select the software modules to match your assay needs:
- Impedance – Track cell proliferation, morphology, and viability label-free and in real-time. Ideal for immuno-oncology, cytotoxicity, virology, cell migration, cell proliferation, GPCR assays, and many more.
- GxP Impedance – Achieve FDA 21 CFR Part 11 compliance in GMP/GLP labs with this version of the Impedance Software Module.
CONSUMABLES
The Maestro Z system is compatible with the 96-well impedance assay plate.
- CytoView-Z™ – The Maestro impedance plate with a transparent well bottom for cell visualization and assay multiplexing. Available in a 96-well plate format.
CROSS-COMPATIBLE PLATFORMS
The Maestro Z system has cross-compatibility with:
- Omni – Compliment your impedance assays with whole-plate images of your cultures. View electrode coverage and culture health over time with just a few clicks in AxIS Z. Compatible with the Omni and Omni Pro 12™ systems.
Brochures
Immunotherapy development: Live-cell tools to accelerate discovery
In this brochure, Axion BioSystems provides information about live-cell tools and technologies for accelerating immuno-oncology research and development. The company's products utilize live-cell assays for a more complete picture of experiments and easier optimization of processes, identification of best candidates, and reliable preclinical data. Axion BioSystems' live-cell platforms allow for the evaluation of in vitro immune cell killing, tumor cell biology, and migration and invasion. The platforms offer whole-well brightfield or fluorescence imaging with single or multiplate options and are compatible with incubators.
Tracking cell proliferation, morphology and viability label-free in real-time
Track cell proliferation, morphology, and viability label-free and in real time
Real-time, label-free assessment of HER2-targeted antibody-drug-conjugate therapies
Antibody-drug conjugates (ADCs), particularly those targeted toward the tumor antigen HER2, have emerged as a popular and effective treatment for cancer patients.
Discover how the effectiveness of ADC therapies in early development were assessed using the Maestro Z™, and how this instrument uses electrodes embedded at the bottom of the well to measure this process in real time so researchers can reveal the precise kinetics of ADC cytotoxicity.
CAR T cell potency assessment with 3D cancer spheroid models
In this application note, Axion Biosystems uses the Maestro Z to develop a real-time, label-free potency assay for immune-cell mediated killing of 3D cancer spheroids.
In vitro potency assays for immune cell-mediated killing with the Maestro Z
Immunotherapy harnesses the power of the innate and adaptive immune system in various ways to seek out and attack cancer. Current immunotherapeutic approaches include monoclonal antibodies that mark cancer cells for improved immune cell recognition and/or recruit immune cells to the site of malignancies, oncolytic viruses that infect and kill cancer cells, and more. In this application note, find out how the Maestro Z is used for immune cell-mediated killing in in-vitro potency assays
Tracking the dynamics of cytotoxicity in real-time
In this application note, Axion Biosystems discuss using the Maestro Z to examine the response of cancer cells and chemotherapy compounds. It presents insights into the kinetics and efficacy of compounds tested and provides evidence for using the Maestro Z for a complete, simple, real-time and label-free method for cell analysis.
T cell-mediated cytolysis of cancer cells
In this application note, Axion Biosystems discuss using the Maestro Z to investigate targeting potency of activated human T cells on cancer cell lines and how the Maestro Z offers a complete solution for simple, real-time and label-free method for continuous cancer cell monitoring and immune cell-mediated cytotoxicity.
TechTalk: Revealing deeper ADC cytotoxicity insights with live cell analysis for drug discovery
Friday, March 20 at 15:00 GMT | 16:00 CET | 11:00 EDT | 08:00 PDT
Antibody-drug conjugates (ADCs) require precise, reliable in vitro assays to understand potency, kinetics, and mechanism of action early in development. Traditional endpoint assays often miss critical dynamic responses and introduce variability through dyes and labels.
In this 20‑minute SelectScience® TechTalk, Field Application Scientist Viswanath Lanka will demonstrate how the Maestro Z™ label‑free monitoring system enables real‑time, impedance‑based assessment of ADC‑mediated cytotoxicity. See how continuous kinetic data reveals differences in killing dynamics, accelerates detection, and supports confident potency quantification.
Register today to learn how to simplify your workflow, improve reproducibility, and apply practical examples of how Maestro Z supports confident decision-making in oncology drug discovery.
Key learning objectives:
- Understand why real-time, kinetic measurements are critical for accurately assessing ADC cytotoxicity
- Learn how label-free impedance assays can be faster and more sensitive than traditional endpoint methods
- Explore practical considerations for implementing real-time ADC assays in discovery workflows
Who should attend?
- Drug discovery, oncology, and ADC‑focused scientists across pharma, biotech, CROs, and academic labs working on targeted therapies, cytotoxicity, and phenotypic screening.
- Assay development, optimization, and cell‑based assay specialists, including lab managers and screening scientists running cytotoxicity, viability, and phenotypic workflows.
- Teams advancing antibody‑drug conjugates, oncology research, and next‑generation drug discovery, with a focus on stability, potency, and decision‑making in early development.
Certificate of attendance
If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.
TechTalk details
- Cost: Free to attend
- Location: Online
- Duration: 20 minutes
Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available
Researchers gain early insights into CAR T efficacy with patient-derived glioblastoma organoids on Maestro Z
New frontiers in glioblastoma: Patient-derived organoids on Axion BioSystems’ Maestro Z impedance-based live-cell analysis system offer new insights into CAR T bioactivity and immunotherapy efficacy
New connected lab functionality that enables easy side-by-side visualization of imaging and bioelectronic data
Axion BioSystems' Maestro MEA and Z platforms now automatically link with Omni imagers, offering enhanced live-cell analysis
