Corning® Supersomes™ Human UGT1A8, 0.5 mL by Corning Life Sciences

Manufacturer Corning Life Sciences  |   Model: 456418  |  Available in North America, Western Europe, Asia, Eastern Europe, Middle East, Africa
Recombinant enzyme prepared from insect cells infected with baculovirus containing human UGT1A8 cDNAsUDP-glucuronosyltransferases (UGT) represent the major phase II drug metabolism pathway in human. UGT enzymes catalyze the transfer of glucuronic acid (derived from UDPGA co-factor) to xenobiotics and endogenous substrates having nucleophilic acceptor groups, making them more polar and readily excreted in urine or bile. To date, at least 18 human UGT enzymes have been cloned and sequenced. Like t... Read more


Corning® Supersomes™ Human UGT1A8, 0.5 mL by Corning Life Sciences product image
Corning® Supersomes™ Human UGT1A8, 0.5 mL
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Recombinant enzyme prepared from insect cells infected with baculovirus containing human UGT1A8 cDNAs

UDP-glucuronosyltransferases (UGT) represent the major phase II drug metabolism pathway in human. UGT enzymes catalyze the transfer of glucuronic acid (derived from UDPGA co-factor) to xenobiotics and endogenous substrates having nucleophilic acceptor groups, making them more polar and readily excreted in urine or bile. To date, at least 18 human UGT enzymes have been cloned and sequenced. Like the P450 enzymes, UGTs possess broad and overlapping substrate specificities. Clinically relevant drug interactions have been identified for UGT isoforms, leading regulatory agencies (FDA) to require drug interaction testing for compounds showing significant UGT metabolism.

UGT1A8 is solely extra-hepatic, predominantly expressed in the intestinal tract. This enzyme demonstrates a high reactivity towards numerous endogenous and exogenous substrates including dietary and environmental carcinogens and drugs. It is an important UGT for drug glucuronidation in the small intestine.

  • Available size: 0.5 mL
  • Protein concentration: 5 mg/ mL
  • Product Overview

    Corning® Supersomes™ Human UGT1A8, 0.5 mL by Corning Life Sciences product image

    Corning® Supersomes™ Human UGT1A8, 0.5 mL

    Manufacturer Corning Life Sciences  |  Available in North America, Western Europe, Asia, Eastern Europe, Middle East, Africa

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