ACQUITY UPLC CSH and XSelect Columns by Waters

"We had been using an older type of C18 column (Symmetry) but switched to XSelect after being advised by Waters. The method transfer to the new column was very easy, results were very well comparable. We only used the XSelect column for a short while now, so I cannot comment on long-term use, but for now results are very consistent. We also use the XSelect Vanguard guard which is easy to use."

"Several attempts to obtain the chromatographic profile of a natural product extract were performed with other columns, which showed about 10 substances in the chemical fingerprint. The XSelect HSS T3 column presented a chromatographic profile of my extract with about 20 substances with incredible separation! Including the substance, I was looking for it was trace in the sample and I did not observe it in the analysis carried out with the other columns. It was a pleasant surprise and I was amazed with the separation profile obtained in LC-MS analyses."

"Water's CSH (Charged Surface Hybrid) columns offer a significant advantage over other types of columns. It offers superior peak shape for nearly all basic compounds, increased loading capacity (meaning more concentrated samples or higher injection volume), rapid column equilibration after changing mobile-phase pH (allows switching between between mobile phases for changing retention order), and it is very stable at extreme pH ranges. Overall, it is a very good column that can be used for a variety of analysis."