Thermo Scientific™ Chromeleon™ 7.3.2 Chromatography Data System (CDS)

Ion-pairing reversed-phase liquid chromatography (IPRP-LC) has been established as the main chromatographic technique for the analysis of oligonucleotide therapeutics, especially when connected to mass spectrometry. However, chromatographic approaches alone still suffer from an inherent lack of selectivity.

Explore how a streamlined approach using Orbitrap-based LC-HRAM-MS platforms can be a valuable tool for the characterization and monitoring of therapeutic oligonucleotide impurities.

Analytical testing labs play a crucial role in monitoring surface, ground, and drinking water for volatile organic compounds (VOCs). Common by-products in the processing of household and industrial products, VOCs can contaminate water sources, potentially harming the environment and public health. Discover how the Teledyne LABS Tekmar Lumin Purge and Trap (P&T) concentrator paired with the AQUATek LVA autosampler, along with Thermo Scientific™ ISQ™ 7610 MS, and TRACE™ 1610 GC system effectively adhere to U.S. EPA Method 524.2 for analyzing volatile organic compounds (VOCs) in drinking water. This advanced setup ensures precise quantitation with superior method linearity, detection limits, and accuracy, meeting stringent regulatory requirements for environmental testing labs.

Thermo Fisher Scientific demonstrates an analytical method that meets the requirements outlined in US EPA Method 624.1 for the quantitation of volatile organic compounds (VOCs) in wastewater, using the Teledyne LABS Tekmar Lumin Purge and Trap (P&T) concentrator paired with the AQUATek LVA autosampler system along with a Thermo Scientific™ ISQ™ 7610 mass spectrometry (MS) system coupled with a Thermo Scientific™ TRACE™ 1610 gas chromatograph (GC) and Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS). Learn about method linearity, detection limits, precision, and calibration checks essential for accurate VOC detection and quantitation in wastewater.

Chromate and dichromate have an oxidation state of +6 and therefore are colloquially known as hexavalent chromium, Cr(VI). Hexavalent chromium is a strong oxidizing, toxic, and potentially carcinogenic agent, and is therefore a regulated compound. Thermo Fisher Scientific demonstrates the determination of 10 ng/L to 200 ng/L hexavalent chromium in a municipal drinking water sample and a synthetic HIW sample, which approximates the composition of a typical municipal water sample, according to modified US EPA Method 218.7 and AU179 on a Dionex™ Inuvion ion chromatography (IC) system.

In this application note, Thermo Fisher Scientific proposes an HPLC-based approach to monitor the characteristics of PS 80 samples that provide operational simplicity while generating a high degree of information.

In both research and development and quality control pharmaceutical laboratories, determining the content of an active pharmaceutical ingredient (API) and its related impurities are typical analyses. While it is common to apply different methods for assay and impurity determination for one API, for instance in many pharmacopoeia monographs, in practice it is preferred to combine both analyses into one single run. Using a software assisted method development approach is hereby a very practical tool to speed up the method development process to save time and resources.

In this application note, Thermo Fisher Scientific presents two workflows for data analysis. Both use the peak area of UV and MS detection for determining the relative abundance of the analyte within the sample. However, the first workflow determines the identity of the analyte by its most intense m/z species. The second one uses deconvolution of the mass spectrum for mass determination and analyte identification.

The analysis of polar ionic pesticides in surface and drinking water as well as food and beverages has become a controversial issue in recent years. The development of genetically modified organism (GMO) crops tolerant to glyphosate (N-(phosphonomethyl)glycine) and glufosinate ((RS)-2-amino4-(hydroxy(methyl)phosphonoyl)butanoic acid), for example, promoted the use of these broad spectrum herbicides. In addition, glyphosate is used as a crop desiccant and to suppress weeds in parks and at roadsides. Consequently, polar pesticides are found in foods as residues and in the environment as contaminants of surface waters and soils.

Developed to improve the analysis of VOC ozone precursors in response to the evolving needs of the EPA Photochemical Assessment Monitoring Stations (PAMS). Our continuous air monitoring system integrates industry leading GC and GC-MS capabilities with superior air analysis products from Markes International.

This poster describes a reliable and easy-to-setup capLC-MS platform for sensitive targeted and shotgun analysis of peptides and proteins. The obtained results were compared with nano and analytical flow LC-MS analysis and recommendations for optimal LC and ESI interface configuration for different proteomics applications were formulated. The optimized capLC-MS conditions resulted in high-throughput separations with ~ 10 min total analysis time for targeted quantification of peptides at amole level.

HERAtech presents its novel automated sample preparation workflow for pesticides and PAHs in surface water with online GC-MS/MS analysis – enabling cost savings through higher sample throughput, reduced solvent consumption and labour time-saving optimization through less downtime. Discover how to optimize your laboratory workflow with unattended operations using Thermo Scientific™ Chromeleon™ CDS software to control the entire system.

In environmental laboratories, analyses of volatile organic compounds (VOCs) and very volatile organic compounds (VVOCs) in water are performed on a routine basis. Dr. Daniela Cavagnino, Product Marketing Manager GC & Autosampler, Thermo Fisher Scientific, discusses these analyses, focusing on headspace sampling techniques. Explore a simple approach to enrich headspace concentration to achieve trace level sensitivity.

Data analysis in the food and beverage laboratory doesn’t have to be complicated. Whether you work in everyday analytical testing or you’re researching unknown compounds, find out how the latest data analysis solutions from Thermo Fisher Scientific could help you to extract value from your data to help protect consumers, your brand and efficiently identify emerging compounds.

Kenneth Gowin, Thermo Fisher Scientific, introduces the latest Thermo Fisher technologies available for customers in Brazil and discusses the opportunities for the science industry. SelectScience Interview for ‘Science in Brazil’ Special Feature.

Watch Marc Yves Chalom, Thermo Fisher Scientific, discuss the opportunities for chromatography and mass spectrometry in Brazil. Hear about the latest capabilities their instrumentation are being used for.

Watch this SelectScience interview with ‘Ice Core Analytical Scientist’ Dr. Ailsa Benton at the British Antarctic Survey in Cambridge. Learn about the challenges involved in drilling ice cores in Antarctica and how advanced analytical techniques, such as Fast Ion Chromatography and ICP-MS, are helping scientists to understand the patterns of climate change, in order to help predict future climates.

Food testing expert, Marco Redaelli, shares his mission to make the world a healthier place, and reveals the technologies helping to deliver more reliable and faster results than ever before

Thermo Fisher and Symphogen extend their collaboration using innovative and efficient workflows to improve data confidence, aiding the creation of new cancer treatments

The new Thermo Scientific Vanquish Method Development HPLC and UHPLC system delivers robust and validated methods in less time with higher confidence

Protein Metrics’ software solutions complement Thermo Fisher’s mass spectrometry systems to facilitate precise, reliable data processing and drive innovation

The Thermo Scientific Orbitrap Exploris GC 240 Mass Spectrometer promises high data quality and versatility to accelerate scientific discovery for academic, industry research, government and omics laboratories

Read the highlights and Q&A from part three of the webinar series: Innovations in Laboratory Efficiency and Analytical Workflows

Thermo Scientific Chromeleon 7.3 Chromatography Data System (CDS) software promises reduced administrative costs, and improved laboratory productivity, and regulatory compliance