Sunshine
The all-around LNP process developer
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Scale it up
Once you’ve found a rock-solid formulation, Sunshine helps you tune in your LNP’s size and design the perfect process to scale them up. Scout ideal flow rates, explore different mixing options, then dial in the right dilution factor to keep them stable. When you’ve got everything just right, Sunshine can shift into continuous mode, making tens of liters in a day. Get process development and scale-up on one platform — who would have figured? Get brochure.
- 10 experiments in 15 minutes
- Fractional & total flow rates
- 1 mL to continuous flow
- 0.1 — 30 mL/min flow rates
- Reusable microfluidics
- Protocol transfer from Sunscreen
Brochures
Sunshine
In this product brochure, Unchained Labs introduces Sunshine, a tool that aids in fine-tuning lipid nanoparticle (LNP) formulations. Once a stable formulation is achieved, Sunshine assists in optimizing the LNP size and designing an efficient scaling-up process. It helps identify ideal flow rates, experiment with various mixing techniques, and determine the correct dilution factor for stability. Sunshine seamlessly transitions into continuous mode, capable of producing tens of liters in a single day. This platform consolidates both process development and scale-up, providing an all-in-one solution for researchers.
Process optimization and pre-clinical production of lipid nanoparticles using Sunshine
In this application note, Unchained Labs introduces Sunshine, a system providing automated process optimization and continuous manufacturing capabilities for the development of nanomedicines. Nanoparticles like lipid nanoparticles, liposomes, and polymer nanoparticles play a vital role in drug delivery, protecting active pharmaceutical ingredients (APIs) and enhancing their effectiveness. Researchers require consistent, cost-effective solutions for nanomedicine development. Unchained Labs offers microfluidics and automation-based nanoparticle synthesis solutions at various stages, from screening and early-stage research to process optimization, enabling seamless progress toward manufacturing and commercialization of drug products.
Flexible nanoparticle development: process optimization & scale-up of a wide range of synthetic nanomedicines with Sunshine
In this application note, Unchained Labs presents Sunshine for nanoparticle development. Nanomedicine, utilizing synthetic nanomaterials like liposomes, lipid nanoparticles (LNPs), and polymer nanoparticles, holds significant promise in drug delivery. These materials enhance the solubility, stability, and bioavailability of active pharmaceutical ingredients (APIs), allowing improved API transport across cell membranes and extending in vivo circulation time, thereby enhancing efficacy and safety. Due to the diverse physicochemical properties of APIs, a flexible nanoparticle generation process is crucial. Sunshine offers an automated microfluidic approach, enabling the development and optimization of milliliter-scale nanoparticle synthesis protocols for various material types and particle structures. It also has the capacity for continuous manufacturing in multi-liter quantities, facilitating pre-clinical testing of a wide range of APIs.
Unchain your lipid nanoparticle development
Discover how to speed up high-throughput screening and production of lipid nanoparticles
