PolyFrit™ fritted CPG

Overcome the challenges of inconsistent performance in small-scale synthesis with PolyFrits™. Designed for high-quality oligo production at nanomole and sub-nanomole scales, PolyFrits embed precise, uniform amounts of solid support within an inert porous matrix to deliver reliable, reproducible synthesis down to 1 nanomole.

Compatible with traditional synthesis methods and techniques, PolyFrits provide a convenient way to handle small quantities of solid support and are well suited to the future of high-throughput DNA and RNA oligonucleotide synthesis.

Why choose PolyFrits for small-scale oligonucleotide synthesis

• Consistent performance with low frit-to-frit variation, typically <10% and often <5%.
• Small bed volumes – as low as 1 mm³, reducing reagent consumption and cost.
• High loading capacity with up to 60% active component by volume.
• Milder manufacturing conditions that better protect the chemical functionality of the solid support.

How PolyFrits work to deliver consistent small-scale synthesis

Traditional sandwiched loose CPG becomes increasingly difficult to load consistently for oligo synthesis below 1 µmol. PolyFrit technology combines the benefits of traditional oligonucleotide synthesis workflows with a standardized solid-support format, helping improve consistency and reproducibility at small synthesis scales.

Improved consistency and efficiency

When compared with traditional sandwich columns, analysis showed that PolyFrit columns delivered higher synthesis efficiency and tighter batch-to-batch consistency, with reduced performance variability.

There are a number of PolyFrit formats available as catalogue products in addition to custom offerings.