NexION 350 ICP-MS Spectrometers

Cisplatin is one of the most widely used platinum-based cancer chemotherapy drugs. Its effectiveness is due to its ability to bind to the cancers DNA, resulting in DNA-platinum adducts, which bends the DNA, resulting in a lack of DNA replication. Despite initial success, cisplatin drug resistance is common in relapse. This application note describes how SC-ICP-MS can be used to explore cellular uptake of cisplatin at the single cell level.

The introduction and development of Single Particle ICP-MS (SP-ICP-MS) has opened a new area of research which allows the rapid detection and analysis of metal-based particles in a variety of matrices and applications.1-6 The key feature of SP-ICP-MS is that it allows discrete pulses of positively charged ions to be detected and measured in a time-resolved manner using microsecond (µs) data acquisition rates. This advance in data acquisition capabilities is opening up a number of new application areas. In this white paper, Perkin Elmer introduces the concept of Single Cell ICP-MS (SC-ICP-MS), where individual cells are rapidly analyzed for metal content.

In this application discover how Campden BRI, a UK based food research organization, has used NexION ICP-MS with unique EDR compatibility for trace elemental analysis in food. Food analysis is particularly an important step in ensuring food quality and safety, with this new technology the sampling at this institution has improved greatly.

With the increasing use of engineered nanoparticles (ENPs) in a variety of products and processes, there is concern about the release of ENPs into and impact on the environment. One aspect of the environmental impact of ENPs that must be explored is their uptake by plants, as ENPs can make their way to plants via migration through water and/or soil. Research limitations can be avoided by careful choice of the ENP extraction procedure and performing the analysis with single particle ICP-MS (SP-ICP-MS), the combination of which will preserve the particle size information, allow for rapid analysis of a large number of samples, and yield results on the particle size, concentration, and size distribution. This application note explores such a technique for analysis of gold nanoparticle uptake in tomato plants.

The focus of this application note is to examine the instrumental conditions and parameters necessary for the coupling of a Clarus® GC to a NexION® ICP-MS system with a GC transfer line and its application towards the speciation of mercury in biological tissues and sediments.

This application note describes a method for the analysis of various food substances using the NexION® 300X ICP-MS, focusing on toxic and typical essential and macro elements in a group of NIST® (Gaithersburg, MD) standard reference materials (SRMs).

This whitepaper is intended to keep the pharmaceutical community abreast of the latest developments with regard to the new chapters on elemental impurities in pharmaceutical products in the United States Pharmacopeia’s (USP) National Formulary (NF). It provides an overview of the salient points described in Chapter <232> on Elemental Limits and Chapter <233> on Analytical Procedures and offered suggestions as how best to approach the determination of elemental impurities in pharmaceutical products using PerkinElmer ICPAES/ OES and ICP-MS instrumentation. It is meant to be the first step in educating pharmaceutical laboratories and explaining why the old “Heavy Metals Test”, described in Chapter <231> is being replaced with these two brand new chapters. The approval of Chapter <2232> –“Elemental Contamination of Dietary Supplements” – is still going through the USP review and comments process.

This application note explores the capability of modern ICP-MS to measure the key characteristics of metal manufactured nanoparticles. ICP-MS is rapidly becoming the elemental measurement technique of choice for assessing the manufacturing and environmental life cycle of engineered nanoparticles. In Standard mode, an ICP-MS provides accurate composition and concentration measurements. In Single Particle mode (SP-ICP-MS), it allows the differentiation between ionic and particulate signals, measures particle sizes (if shape is known), and explores agglomeration and size distribution.

This case study presents Dr. Ranville of the Colorado School of Mines research in the area of nanoparticle sensitivity and specificity involving the use of ICP mass spectrometry (ICP-MS). Because of its trace element capability, and extremely low detection limits, the technique is ideally suited to the characterization of ENPs, containing elements such as Ag, Au, Ti and Fe, which have been integrated into larger products such as consumer goods, foods, pesticides, pharmaceuticals, and personal care products. The ubiquitous use of goods containing these nanomaterials will inevitably lead to environmental releases, which may be studied and quantified using state-of-the-art ICP-MS technology, such as PerkinElmer’s NexION® 300Q system, which was acquired recently.

This case study presents a decision by the Environmental Resource Associates (ERA) to install the PerkinElmer NexION® 300 ICP-MS for use in inorganic proficiency testing. This decision was based on the need for a new instrument to keep up with an increasing workload. The stability of the NexION 300 ICP-MS enables users to run for many hours without recalibration.

PerkinElmer’s Suneet Chadha accepts the Scientists’ Choice Award for Best New Spectroscopy Product of 2014 for the NexION 350 ICP-MS Spectrometers. The global SelectScience community nominated and voted for this prestigious award, which was presented at an exclusive VIP ceremony at Pittcon 2105 in New Orleans, LA.

Watch this video to find out more about the PerkinElmer NexION® 300. This breakthrough technology changed expectations of an ICP-MS by being the first instrument to feature: three modes of operation (Standard, Collision, Reaction) to suit any application; three cones (sampler, skimmer AND hyper skimmer) for stability; three quadrupoles to maximize sensitivity for every element in a run. See the difference…

The NexION 300 ICP-MS offers both the simplicity and convenience of a collision cell and the detection limits of a true reaction cell. The video takes a tour of the instrument from the samples viewpoint highlighting the various applications, innovative features and benefits along the way. With patented Universal Cell Technology™, analysts can choose the most appropriate technique for a specific sample or application.

Watch this interview to learn more about the new NexIonTM 300 ICP-MS. The system has three interference modes (standard, collision and reaction) and can be switched from one mode to another easily. Key features include high stability, ease of use and the universal cell technology. Pittcon 2010 interview with PerkinElmer

Detecting engineered nanoparticles (ENPs) in food crop using SP-ICP-MS

Hear what the UNIRIO professor has to say

Hear what Biomnis' Analytical Chemistry Department Manager has to say

Awards presented during prestigious ceremony at Pittcon 2015

Separations, Spectroscopy, General Lab and Reviewers' Choice Awards announced at Pittcon