An Introduction to Single Cell ICP-MS Analysis

11 May 2017

The introduction and development of Single Particle ICP-MS (SP-ICP-MS) has opened a new area of research which allows the rapid detection and analysis of metal-based particles in a variety of matrices and applications.1-6 The key feature of SP-ICP-MS is that it allows discrete pulses of positively charged ions to be detected and measured in a time-resolved manner using microsecond (µs) data acquisition rates. This advance in data acquisition capabilities is opening up a number of new application areas. In this white paper, Perkin Elmer introduces the concept of Single Cell ICP-MS (SC-ICP-MS), where individual cells are rapidly analyzed for metal content.

NexION 350 ICP-MS Spectrometers

PerkinElmer

When your instrument is more efficient and productive, so too are your scientists and your lab. And nothing puts the flow in your workflow better than the NexION® 350 ICP-MS. With a data acquisition speed 10 times faster than any other ICP-MS on the market, the new NexION 350 ICP-MS opens up a whole new world of efficiency and opportunity, allowing you to measure more in less time, and accurately characterize nanoparticles. In addition to the exceptional application flexibility afforded by its speed, the instrument also delivers superior uptime and productivity through a variety of unique features engineered to enhance signal stability: Triple Cone Interface produces the industry’s most tightly focused ion beam and prevents sample deposition on internal components. Quadrupole Ion Deflector turns positively charged ions 90° into the Universal Cell and filters off neutrals. Analyzing Quadrupole made of a unique steel alloy for negligible thermal expansion for unparalleled stability. No extraction lenses to clean for minimized maintenance.

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An Introduction to Single Cell ICP-MS Analysis