Millicell® ERS 3.0 Digital Voltohmmeter
Top TEER Monitoring.
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Experience a better way to TEER. The Millicell® ERS 3.0 streamlines data capture with intuitive, user-friendly enhancements. Achieve more stable measurements using a self-standing, in-well probe. Keep track of your results with real-time, on-instrument resistance and voltage data recording. Simplify analysis across wells and between experiments using a cloud-based application. Obtain consistent readings with low noise, greater resolution, and high accuracy. Optimize your transepithelial electrical resistance experiments with the Millicell® ERS 3.0.
2.5D cell culture models for more predictive in vitro research
2.5D cell culture is an emerging approach for creating more physiologically relevant in vitro models, overcoming key limitations of conventional 2D systems. Using microporous membrane inserts restores apical-basolateral polarity, supports barrier formation, and enables air-liquid interface (ALI) culture—critical for differentiated epithelial models with improved predictive value for ADME/Tox, drug transport, and disease research.
2.5D culture bridges simple monolayers and complex 3D systems. It allows organoid-derived cells to be grown on permeable membranes, combining biological relevance with accessibility for TEER measurement, permeability, migration, and wound healing assays. Tools such as Millicell® inserts and plates support applications from GI barrier and drug absorption studies to skin and respiratory models, enabling more predictive epithelial and tissue-representative systems.
Download this SelectScience guide to explore:
- How to culture colon organoid monolayers for GI barrier research
- Small intestine organoid-derived monolayers and physiologically relevant alternatives to Caco-2 models
- Optimizing MDCK cell culture for high-throughput TEER and permeability assays
- The principles behind barrier formation and permeability assays using cell culture inserts
- Generating organotypic air-liquid interface 3D skin cultures
- Modelling respiratory lung diseases using bronchial epithelial cells at ALI
Resource details:
- Document type: SelectScience guide
- Page count: 47
- Read time: 85 mins
- Edition: 1st
Optimization of Caco-2 cell growth and differentiation for drug transport assay studies using Millicell 96-well cell culture plates
This application note demonstrates how to optimize Caco-2 cell culture conditions for reliable drug transport and permeability studies using the Millicell 96-well plates. It outlines protocols for cell growth, seeding density optimization, and monolayer integrity assessment, alongside methods for measuring drug absorption rates. The workflow supports high-throughput screening of candidate compounds and provides reproducible in vitro data to inform drug discovery and ADME evaluation.
Top TEER monitoring with the Millicell ERS 3.0 Digital Voltohmmeter
Merck explores the innovative features of the Millicell® ERS 3.0 digital voltohmmeter. This advanced system streamlines data capture with intuitive, user-friendly enhancements. The video demonstrates how the self-standing, in-well probe ensures more stable measurements and highlights the convenience of real-time, on-instrument resistance and voltage data recording. Explore how the Millicell® ERS 3.0 can enhance laboratory workflows and improve data accuracy.
