MicroCal PEAQ-DSC
Gold standard protein stability analysis for research applications
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Great results, basic equipment for our lab, we love it.
Analyzing biotechnological proteins
We're very happy to have an instrument like this, the results and usage are very user friendly. It's not for everyday use in the lab, but we've a method where this equipment is essential. We also have the experience of having a Malvern nano Zetasizer that we love too
Review Date: 15 Jan 2021 | Malvern Panalytical
Manufacturer's Response
Thanks you for your review, so glad to hear that you have several of our products that you use every day in your lab.
Great instrument. Good-quality results.
Protein biophysics
This is a great instrument to achieve high-quality data. Both the instrument and the packaged software are user-friendly. Easy to learn, easy to use.
Review Date: 5 Jul 2019 | Malvern Panalytical
Manufacturer's Response
Thank you, we put a lot of emphasis on ‘the ease of use’ of the instrument during the development. It is gratifying to hear that you think we have made some progress in that area. Thanks again.
The MicroCal PEAQ-DSC system provides highly sensitive, easy-to-use microcalorimetry that helps reduce the time and cost associated with stability testing and comparability analysis. The MicroCal PEAQ-DSC is a manual instrument with a cleaning device, which can be upgraded to an automated version upon request.
Data generated by the MicroCal PEAQ-DSC provides critical guidance for biopharmaceutical development in protein engineering, (pre)formulation development, process development, manufacturing change control and biosimilarity and biocomparability studies. The integrated software streamlines workflows, facilitates non-subjective data analysis, performance qualification and compliance with 21 CFR Part 11 and Annex 11 regulations, all delivering high integrity data and driving productivity in biopharmaceutical research.
Key Features:
- Gold standard stability-indicating technique requiring minimal assay development
- Direct and label-free measurement of biomolecular native-state stability in solution
- Measurement of very tight binding constants, up to 1020M-1
- Manual system with pipette and cleaning device
- Powerful MicroCal PEAQ-DSC software minimizes typical data analysis time and includes:
- PEAQ-Compliance: The system is available with Malvern Panalytical Access Controller (MAC) to limit access to user-defined SOPs and data analysis features. Data can be displayed using the Report Generator with user details and the ability to sign using electronic signatures to facilitate the integration of the workflow into your company’s quality system and aid compliance with 21 CFR Part 11 and Annex 11 regulations. This is provided as an optional accessory
- PEAQ-Performance: Automatically detects and validates system readiness for optimal performance
- PEAQ-Smart (including PEAQ-Finder): For SOP-based operation and data analysis. Provides new algorithms to detect even subtle peaks and shoulders, facilitating the automatic, non-subjective identification of multiple transitions, such as those seen in multi-domain proteins
- PEAQ-Compare: For the quantitative comparison of DSC traces for comparability studies, ideal for batch-to-batch and biosimilarity studies
- Network-ready: email updates sent during the analysis to keep you informed of assay progress
Differential scanning calorimetry: Your guide to analyzing proteins for vaccine stability
In this application note, Malvern Panalytical describes how differential scanning calorimetry (DSC) can help to optimize your process and speed up the selection of vaccine candidates.
Ultimate guide to viral vector characterization in cell and gene therapy
Viruses, such as adenoviruses, retroviruses, and adeno-associated viruses (AAVs), have been utilized as vectors in cell and gene therapy for decades. In biopharmaceutical research, gene therapy has become an area of continued growth, but is not yet a commercially viable drug platform.
Download this eBook to help strengthen your analytical workflows and accelerate viral vector characterization, development, and scale-up. Including a peer-reviewed article, application notes, and product guides, this eBook will steer you through the complexities of viral vector characterization to help you bring successful nanomedicines and nano-delivery systems to market, including:
- Characterization of recombinant rAAVs
- AAV attributes
- Enhanced characterization
- Multi-detection SEC in gene therapy
- Measuring the concentration of AAVs
Biomolecular stability analysis for the regulated environment
Differential Scanning Calorimetry (DSC) is a powerful analytical technique which characterizes the thermal stability of proteins and other biomolecules. In solution, these molecules often undergo thermally-induced conformational changes, such as the breaking of non-covalent bonds leading to the unfolding of a protein. The information delivered by DSC is ‘gold standard’, label-free stability data which can be used for a variety of purposes.
Biophysical Application of Calorimetric Methods to Protein Misfolding And Aggregation Examinations
Unfolded proteins fold into thermodynamically-favorable native structures under the correct physiological conditions for gain of function. This whitepaper describes how differential scanning calorimetry and isothermal titration calorimetry can be used as a powerful method for the thermodynamic investigation of interactions between diverse biomolecules and inorganic compounds. It details some examples from literature of the methods application in studying amyloid fibrillation.
Live Launch of Malvern MicroCal PEAQ-DSC
In this video, Malvern unveil the new MicroCal PEAQ–DSC, a stability characterization technology for biopharmaceutical molecules. The MicroCal PEAQ–DSC delivers automation, high-throughput, accuracy and reproducibility to laboratories involved in biomolecule assessment.
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