Metabolomics and Cellular Metabolism
Stable Isotope-labeled Metabolites in MS-based Methods
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Metabolomics is an increasingly important and growing area of research. The use of stable isotope-labeled metabolites in MS-based methods allows researchers to identify/quantify metabolites in sample matrices. This information may be used to better understand the physiology of an organism, its response to a drug, and its change to an environmental stimulus. It can also be used to unravel disease mechanisms and to assess putative biomarkers. Toward these and other directives, CIL offers a library of well-characterized stable isotope-labeled standards (spanning a multitude of metabolic classes and pathways) that are available individually and/or as multi-component mixtures. The mixes, which are predominantly available in their neat form for enhanced user flexibility, are designed to aid ease of use in untargeted or targeted metabolomics (be it for quality control, qualification, and/or quantification). In select cases, the mixes are available as kits, with a user manual (accessible via QR code) supplied with the mix(es). The manuals outline general procedures and processing examples, as well as alternate method suggestions and analysis results for guided user reference.
From QC to quantitation: Utility of QReSS metabolites in FBS measurements
Metabolomics is a rapidly growing field of research that has unique and proven advantages in systems biology and biomarker discovery. Great advances have been made over the past decade on the feasibility of mass spectrometry (MS)-based metabolomics. Despite the advancements, there remains a pervasive need for quality control (QC) as metabolomic experiments can experience unwanted variations that threaten the quality of the acquired data. The use of reliable QC measures is therefore critical to assess and prevent unwanted preanalytical and instrumental variation.
In this application note, the QReSS™ standard mixes (CIL cat no. MSK-QReSS1 and MSK-QReSS2) were used in the QC of metabolites from variably sourced FBS samples.
Resource details:
- Resource type: Application note
- Page count: 8
- Read time: 6 mins
