Mastersizer 3000

Grating-coupled interferometry (GCI) is ideally suited for fragment-based drug discovery due to inherent sensitivity of the detection principle, and the ability to capture fast transitions. It uses the refractive index changes that occur with protein binding and are measured as time-dependent phase-shift signals. Explore how the Creoptix® WAVEsystem combines GCI with innovative no-clog microfluidics, permitting the study of biomolecular interactions using crude, unpurified samples, or in complex matrices, such as serum, plasma, or cell supernatant. The WAVEsystem uses a robust sensor and microfluidics cartridge, the WAVEchip®, with four parallel flow channels, available in different surface matrix chemistries suitable for diverse applications, such as protein, antibody, VLPs, lipids, and others.

The development of small molecule drugs is a costly and high-risk venture fraught with challenges at every stage of the pipeline.

In this new eBook, we present a range of state-of-the-art physicochemical technologies and techniques designed to streamline formulation development, accelerate approval processes, and ensure the consistent and compliant manufacturing of safe, efficacious drugs.

Download it free today to explore analytical solutions for:

• API and excipient characterization
• Establishing in vitro bioequivalence
• Discriminating between polymorphs
• Elemental impurity analysis
• Troubleshooting and root cause analysis

In this article, Malvern Panalytical introduces a toolkit for the analytical characterization of Li-ion batteries. These technologies aim to address many of the development and manufacturing challenges faced by battery production in order to meet the increasing demand for low-cost, lightweight, long-lasting and stable power sources.

In this case study, Justin Hoover, Quality Manager at Metals and Additives LLC, discusses the company’s requirement for an instrument that was more efficient, versatile and accurate for particle size analysis.

This white paper from Malvern considers a range of sampling methods for particle size analysis, such as the mass of sample required, the reliability and practicality of the sampling methods, the implication for product homogeneity and the use of laser diffraction for particle size measurements.

Additive manufacturing is ‘the process of joining materials to make objects from 3D model data, usually layer upon layer, as opposed to subtractive manufacturing methodologies such as machining’. Identifying analytical tools that can be used to reliably set specifications for AM metal powders to validate quality and manage their use is vital. In this white paper, Malvern Instruments reviews the key processes used in AM and how they determine the requirements of metal powders for this application.

The critical strength and curing properties of cement are dependent on the particle size distribution resulting from the grinding phase. In this application note, laser diffraction was used to measure particle size in samples of the raw mix and two cement blends using the Mastersizer 2000. It demonstrates that laser diffraction is a fast and effective technique for measuring the particle size of cement. Additionally, the broad size measuring range of the Mastersizer 2000 meant that the same lens could be used to measure particle size in the raw mix as well as extra fine cement grades.

Particle size defines the performance of a wide range of different products, meaning measuring relevant particle size data is therefore essential in many industries. This whitepaper provides helpful tips on how to develop an efficient, robust method that will deliver reliable and reproducible data. It covers effective sampling, sample preparation, pressure titration and measurement optimization, in addition to giving troubleshooting advice and tools.

To improve its shelf-life, milk undergoes a homogenization process. This process produces fat globules of a uniform, small size. Milk also contains casein micelles, which play a role in stabilizing the fat globules. The size of the fat globules and the proportion of free casein micelles are important parameters for monitoring the homogenization process. Find out how these can be measured by laser diffraction, in this application note.

This whitepaper describes the drawbacks of sieving, and how a move to laser diffraction technology can optimize manufacturer’s analytical productivity and efficiency. It compares sieving to laser diffraction and details five reasons why laser diffraction is superior in most manufacturing settings. These include faster analysis, increased measurement range and better measurement resolution.

This year’s Reviewers’ Choice Award for Analytical Science Customer Service of the Year went to Malvern Panalytical. In this video, Dr. Anne Virden, Product Manager Micro Materials at Malvern Panalytical, highlights the value of user reviews. Virden explains how customers are always at the center of what the company does and how product reviews on SelectScience enable Malvern Panalytical to truly understand their customers’ needs.

Take a look at the reviews left by scientists around the world for Malvern Panalytical’s products and leave your own reviews on the lab equipment you use.

Watch this presentation by Dr. Anne Virden and Dr. Debbie Huck-Jones, Malvern Panalytical, titled: Physico-alchemy: Optimizing drug formulations through measurements at the microscale. This talk was presented at the SelectScience® Virtual Analytical Summit 2021.

Watch this video to discover the Hydro Sight™, a revolutionary accessory for the Mastersizer range of instruments providing rapid visualization and assessment of your liquid particle dispersion during a measurement. Real-time observation of the particles in the laser diffraction measurement flow allows improved understanding of how stirring and sonication or the addition of surfactants and stabilizers affect your dispersion.

Watch this video to learn about the Mastersizer 3000 from Malvern. This particle size analyzer offers rapid and efficient liquid sample dispersion, as well as optimized dry dispersion for fragile or robust powders. Samples can be analyzed within a wide 10nm to 3.5mm range, with software that eases your analytical workload.

The Mastersizer 3000 laser diffraction particle size analyzer delivers rapid, accurate particle size distributions for both wet and dry dispersions with the minimum of effort. Measuring over the nanometer to millimeter particle size ranges, it packs exceptional performance into the smallest of footprints, bringing operator-independent measurements that every user can rely on.

Creoptix’s WAVEsystem offers a breakthrough level of kinetics analysis and will now form a critical part of Malvern Panalytical’s expanding drug discovery solutions

Sunil Patel reveals the key technology behind reliable pharmaceutical formulation and finished product analysis at Intas Pharmaceuticals

We reveal the cell counters, LC systems and particle size analyzer that have earned one of these coveted awards based on exceptional reviewer feedback

Find out how laser diffraction particle analyzers are reducing production time and improving quality assurance processes in coffee manufacturing

Erlab, Specac, Eppendorf, Malvern Panalytical and Thermo Fisher Scientific are among the latest companies recognized for highly-rated products

Malvern Panalytical instrument used for testing planetary field geology and mineralogy at terrestrial analog sites in Arizona and Utah

Waters, BioTek Instruments, PerkinElmer, Hamilton among the latest companies recognized for top-rated lab products that scientists worldwide love to use

More top-rated products gain a coveted new SelectScience Seal of Quality, helping you to choose the best for your lab