MicroCal PEAQ-ITC
Designed for ease-of use and exceptional sensitivity
MicroCal PEAQ-ITC
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Great for binding kinetiks of proteins
Protein binding studies
It needs some practice to produce good results as it is very sensitive. With a bit of practice results are very good, reproducible and the sensitivity is really high.
Review Date: 14 Oct 2022 | Malvern Panalytical
Manufacturer's Response
Thanks so much for the feedback. We are very happy that you like our aftersales support and that the instrument is good value for money. We take your comments on ease of use very seriously and will do our best to make initial interactions with instrument easier for new users.
It is the masterpiece for the Protein biologist.
Protein-Protein Interaction
MicroCal Peaq ITC is easy to use with a fully automated wash module. The integrated analysis software is very helpful with the inbuilt models to detect the mode of binding. The machine and software is easy to use. The equipment will be useful for the researchers to evaluate the protein-protein, protein-nucleic acid, and small molecule interactions. This will be helpful to determine the binding affinity for the any interaction. The analysis will also suggest the mode of binding and the type of binding if it is hydrophobic or ionic interaction. The equipment is fully automated with ease of use. The titration is well controlled and the experiment can be performed at various temperatures.
Review Date: 6 Sept 2022 | Malvern Panalytical
Great to greatest results, cant imagine research without this
DNA Protein interaction
The MicroCal PEAQ-ITC is a highly efficient product in terms of providing excellent results and with high accuracy and repeatability. The product is very handy to study DNA-Protein interaction, PNA interactions, etc. very easy to use and less maintenance, ambient temperature is sufficient. As of my knowledge, the product is best available as of now. Very easy to use, requires less time to start titration around 2 minutes. Extraordinary service support. The best product we can get for the money you spend.
Review Date: 15 Dec 2021 | Malvern Panalytical
Manufacturer's Response
Thanks for the feedback. We are so happy to hear it is making a difference in your DNA-Protein interaction studies.
Great equipment, worth the price
Binding affinity between proteins
Easy to use. Produces reliable data. Neat software
Review Date: 15 Dec 2021 | Malvern Panalytical
Manufacturer's Response
So glad you like the software and reliability of the PEAQ ITC data. Thank you for the feedback.
Great equipment
DNA and protein interaction
I tried to use ITC to detect the interaction between protein and nucleic acid. Obviously, ITC's instrument is very accurate, which requires a very high amount of samples. Therefore, I repeated it many times to get trendy experimental results
Review Date: 15 Dec 2021 | Malvern Panalytical
Manufacturer's Response
Thanks so much for the feedback. Nice to know the ITC is helping you in your protein interaction research. We’d love to hear more about your application, I know your local Malvern Panalytical applications team would love to hear about your results.
Can't live without this instrument.
Kinetic and thermodynamic parameters of a protein drug target
ITC has become my bread and butter instrument for biochemical characterization because it uses small quantities, provides precise, reproducible results, and is label-free. I run a small lab, so getting all of those things for both kinetics and thermodynamics is gold! The drawback of ALL ITC instruments is, of course, how many runs you must do before you find the magic protocol and concentrations, but I will take that over designing multiple, label-dependent assays.
Review Date: 13 Aug 2021 | Malvern Panalytical
Manufacturer's Response
Thanks so much for taking the time to write the review. It is so nice to hear your story and the positive contribution the instrument is making to your research. Thanks also for the great advice, we will work on making it easier to find the “magic protocol’.
This instrument is great and it allowed me to expand my research horizons.
Analyze biomolecule interactions and binding
The MicroCal PEAQ-ITC is a very versatile equipment. Trough ITC experiment it is possibile to obtain a lot of information regarding the thermodynamics, the mechanism and the stoichiometry of the binding between two molecules in solutions. Additionally, you can exploit it in order to describe quantitatively and qualitatively fundamental phenomena underlining nanotechnologies such as the self-assembly of amphiphilic molecules. The instrument is easy to use also by a beginner user and the maintenance is extremely light. Thanks to the automatization of the cleaning step and the relative less time-consuming, it is possible to carry-out up to 12 experiments during the day.
Review Date: 13 Aug 2021 | Malvern Panalytical
Manufacturer's Response
Thank you so much for comments and for taking the time to review. It is so nice to see that you think it is easy to use and good for beginners. A lot of thought went into that aspect of the instrument design, and it is great to hear that we made some progress. Thanks also for pointing out the less well-known application of self-assembly studies. It sounds like you are working very hard with 12 runs a day and we wish you every success in your research.
Easy to use and reliable.
Analyze protein inhibitors
Very easy to use and reliable calorimeter. The accompanying software is highly intuitive and helps the user in designing ITC experiments and analyzing the obtained results.
Review Date: 30 Oct 2020 | Malvern Panalytical
Manufacturer's Response
Thank you for taking the time to provide this much-appreciated feedback. We’ll pass it on to the development team to brighten their day. We also know that things can always be improved and it would be great to hear any suggestions you may have. Thanks again and take care.
Great data, fast to be obtained, easily interpretable! Useful for small molecules!
Analyzed lead compounds (small molecules) that inhibit an enzyme
ITC is a friendly technique, and this instrument has been upgraded, making it quite robust and easy to use. For biochemists, PhD students as well as PostDocs, it represents an excellent source of info for studying protein-small molecules interactions. If your molecules are water soluble or solubility can be achieved by adding a small amount of organic solvent to your buffer solutions, it is the method of choice to obtain thermodynamic parameters for your lead molecules, affinity constant, enthalpy, stoichiometry of interaction and so on... Last but not least, it helps a lot when you want to know if any compounds do their job by interacting directly with your target or not.
Review Date: 28 Aug 2020 | Malvern Panalytical
Manufacturer's Response
Thank you Professor Cendron. It is very kind of you to write this. As part of the team that developed the PEAQ-ITC, it is very gratifying to hear that we have been successful, at least in part, at making the instruments user friendly and robust.
Great instrument, good service.
Protein metal binding
I like the instrument design. It is easy to operate, all parts seem very sturdy and there are no extra elements. Malvern did a good job writing the manual for this instrument which is helpful for troubleshooting your experiment and also for maintenance. The software is nice and user-friendly, has a lot of functions that can help you analyze your experiment in the best way. The only issue is that the equations used for calculations are not provided in the software, they are discussed in the manual. As a visual person, I would prefer seeing all calculations but that's just me. After installation, we had a few training sessions (one with the service engineer and another with the application specialist) which were definitely enough to start using the instrument with confidence. As for the maintenance, we recently had our annual check and everything was fine. The engineer came for a day, tested and cleaned our instrument. The only issue was the communication with the service engineer as he was not the best in responding and it took some time to schedule his visit. Many thanks to Stoyan who always answers all questions about experiment design and data analyses. His experience definitely helps in troubleshooting.
Review Date: 13 Mar 2020 | Malvern Panalytical
Manufacturer's Response
Thank you. Very nice to hear that you like the instrument. Thank you also for the feedback on the timeliness of our response to scheduling a visit. We have fed that back to the team. I encourage you to reach out to your local representative who will be happy to assist you and ensure that doesn’t happen again.
The MicroCal PEAQ-ITC is a highly sensitive, low volume isothermal titration calorimeter for the label-free in solution study of biomolecular interactions. It delivers direct measurement of all binding parameters in a single experiment and can analyze weak to high affinity binders, using as little as 10µg sample. Semi-automated maintenance minimizes operator intervention and the system is upgradable to the fully automated MicroCal Auto-iTC200, making it ideal for laboratories where speed, sensitivity and the ability to accommodate higher workloads in the future are paramount.
Features:
- User-friendly guided workflows with embedded help videos give any level of user the ability to generate high quality data.
- High signal to noise gives more confidence in accessing data quality and relevance of generated affinity and thermodynamic parameters.
- Automated washing with detergent of the sample cell and titration syringe assists in producing high quality reproducible data.
- All binding parameters (affinity, stoichiometry, enthalpy and entropy) in a single experiment.
- Quick to first results with no assay development, no labeling, no immobilization and no molecular weight limitations.
- Sensitivity to investigate any biomolecular interaction using as little as 10µg of protein.
- Directly measures millimolar to nanomolar affinities (KDS) (10-2 to 10-9 M).
- Measures nanomolar to picomolar disassociation constants using competitive binding techniques (10-9 to 10-12M).
- Nonreactive Hastelloy for chemical resistance and compatibility with biological samples.
- Compatible with non-aqueous solvents.
- Upgradable to fully automated MicroCal PEAQ-ITC Automated.
