Kinetex Biphenyl Columns

In this poster, Phenomenex focuses on tracking designer benzodiazepine substances obtained illicitly. LC-MS/MS techniques are crucial for the proper identification and quantitation due to cross reactivity with benzodiazepine immunoassay kits. The study targets 14 compounds in urine using high-sensitivity fast LC analysis. A Kinetex™ Biphenyl LC column is used for chromatographic separation, coupled with a SCIEX® 4500 triple quad for MS/MS detection.

In this application note, Phenomenex focuses on tracking and detecting synthetic benzodiazepines using effective LC-MS/MS techniques. The study quantifies 14 compounds in a urine matrix with high-sensitivity using fast LC analysis. The panel includes 13 "synthetic" benzodiazepines, and Alprazolam is added for necessary differentiation. Strata®-X-Drug B Plus is chosen as the ideal SPE plate, and a Kinetex® Biphenyl LC column is used for chromatographic separation.

In this application note, serum was cleaned up and compared with both a single protein precipitation protocol and also by the addition of a phospholipid removal product. The analysis was analyzed with a Kinetex 2.6 µm Biphenyl LC column to show the separation similarities. The phospholipid traces show the differences between the two clean up techniques and displays why Phree is a necessary addition to the clean up steps along with the comparative recoveries for the two techniques.

In this application note, Strata-X-Drug B Plus Solid Phase Extraction (SPE) is used for an easy clean up solution for the urine sample matrix. It uses an in-well beta glucuronidase hydrolysis to save time and transfer steps. The SPE method does not require conditioning or equilibrations steps for additional times savings. When combined with a core shell Kinetex Biphenyl column, recoveries are between 71 112% and good separation of analytes.

Whole blood is a common matrix for toxicology testing, yet it can be very complicated to clean up. Using Phree Phospholipid Removal as a pass through with an easy protein precipitation, the whole blood matrix is efficiently cleaned up while still yielding high recoveries and low variation before analysis on LC MS/MS using a Kinetex Biphenyl LC column.

Food samples may contain naturally harmful substances such as mycotoxins. In this application note, a method was demonstrated for the monitoring of four target mycotoxins in cannabis products.

This application note demonstrates the preparation and extraction of corticosteroids from urine samples using Phenomenex Solid Phase Extraction (SPE) and Kinetex Core-Shell LC Columns.

In this technical note, Phenomenex demonstrates a method for LC-MS/MS analysis of cannabinoids with the Kinetex Biphenyl core-shell column.

This application note discusses sample preparation techniques for a variety of clinical samples for simplified liquid extractions (SLE) and solid phase extraction (SPE).

Multi-class pesticide screens are a very common environmental and food-based analysis that serves to check and ensure the use of highly-regulated compounds in food stuffs and agricultural samples are safe. As pesticide residues are known to be potentially harmful to both human and animal health, the current trend of this analysis has focused on the use of very large LC/MS/MS screens for compound identification and quantification. This application note presents the Kinetex 5 µm biphenyl core-shell column, capable of a comprehensive screening of over 180 pesticides.

Have you got a separations problem? Perhaps chromatography can solve it. All you need is the right method!

Roy Gerona, Assistant Professor, UCSF, discusses the technology that allows his laboratory to perform cutting-edge mass spectrometry in designer drug surveillance and hair analysis in other fields

Phenomenex CEO Fasha Mahjoor gives SelectScience an insight into his top tips for business success

Discover how the Department of Clinical Immunology and Biochemistry at Vejle Hospital is improving diagnostics & patient care using liquid chromatography