Comparison of two clean up techniques and a quick analysis of 39 pain management drugs from serum
12 Jul 2021In this application note, serum was cleaned up and compared with both a single protein precipitation protocol and also by the addition of a phospholipid removal product. The analysis was analyzed with a Kinetex 2.6 µm Biphenyl LC column to show the separation similarities. The phospholipid traces show the differences between the two clean up techniques and displays why Phree is a necessary addition to the clean up steps along with the comparative recoveries for the two techniques.
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Kinetex 2.6 µm PS C18
Phenomenex IncThe new Kinetex 2.6 µm PS C18 phase is beneficial for all types of compounds (acids, bases, neutrals), but especially for the analysis of polar basic compounds. The phase has demonstrated increased polar analyte retention, improved peak shape for troublesome basic analytes under typical reversed phase conditions, and a unique multi-modal interaction selectivity making it indispensable tool for multi-compound and metabolite profile screens.
