Is poor sample prep impacting your bioanalytical methods?

Sample preparation plays a critical role in liquid chromatography-tandem mass spectrometry (LC-MS/MS) workflows, yet traditional protein precipitation can leave behind phospholipids that compromise sensitivity, contaminate instrumentation, and reduce analytical robustness.

Demonstrated in a study, explore this resource to learn how phospholipid removal (PLR) compares with traditional protein precipitation for biological sample preparation. The results highlight that PLR eliminated signal suppression of up to 75% without compromising analyte recovery, showcasing its ability to deliver cleaner samples and more dependable quantitation. See how improved sample preparation can support analytical robustness, reduce downstream challenges, and help laboratories get more value from every LC-MS/MS analysis.

Resource details:

Resource type: Application note
Page count: 9
Read time: 14 mins