icon96™
Stop gambling on cycle numbers. The icon96 uses iconPCR™ technology with AutoNorm™ software to provide real-time fluorescence feedback in each of 96 independent wells, preventing under-amplification dropouts and over-amplification artifacts—delivering balanced, sequencing-ready libraries without manual quantification or normalization.
icon96. 96 individually controlled wells means normalized, sequencing-ready libraries in one step
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Every NGS library prep risks under-amplifying precious samples into dropouts or over-amplifying them into chimera-filled garbage data—and you won't know until it's too late. The icon96 solves this with iconPCR™ technology: 96 individually controlled thermal zones with real-time fluorescence detection. AutoNorm™ software monitors every well and stops each reaction at its optimal cycle, ensuring data quality and workflow efficiency in one automated step.
Improve Sequencing Data Quality:
- Eliminate dropouts: Real-time monitoring prevents under-amplification failures—critical for precious clinical samples like FFPE, cfDNA, or biopsies you can't re-collect
- Reduce artifacts: AutoNorm stops reactions before over-cycling creates PCR duplicates, chimeras, or adapter dimers that compromise sequencing data quality
- Rescue variable-quality samples: Automatically adjusts cycles for degraded or low-input samples (DIN 1.3–8), avoiding both failed libraries and over-amplification distortions
Relieve Library Prep Workflow Bottlenecks:
- 96 → 1 cleanup: Pool libraries by volume directly after PCR; perform one SPRI cleanup instead of 96 (saves ~$225/plate)
- No manual normalization: AutoNorm delivers every sample at the same target fluorescence—sequence-ready without Qubit quantification, TapeStation analysis, or dilution steps
- Flexible throughput: Run RNA-seq, 16S metagenomics, single-cell, WGS, or FFPE workflows (and more coming) on the same instrument with any existing kit—no proprietary consumables required
- Time savings: Complete library prep to sequencing pool in under 3 hours versus 8+ hours with traditional workflows
How It Works:
The icon96 features 96 miniaturized thermocyclers with precision temperature control and real-time fluorescence detection in every well (iconPCR technology). AutoNorm monitors library amplification every cycle and automatically stops individual wells when they reach optimal yield—preventing both under- and over-amplification across variable inputs (0.6 ng to 1000 ng) without prior sample quantification.
The Bottom Line - Why it's iconic:
- 96 wells, each with independent control
- AutoNorm: No more manual quant or normalization
- Every sample gets its perfect cycling—no batching
- Real-time feedback, automatic cycle adjustment
- Save low-input and tough samples with fewer failures
- One simple cleanup—ditch individual SPRIs
- Works with your kits and workflows—no “locked-in” extras
- Faster prep, lower costs, better data quality
