GCMS-TQ8040 NX Triple Quad Gas Chromatograph Mass Spectrometer

In this application note, Shimadzu presents examples of analyses to compare wild and genetically mutated Drosophila and analyze differences in metabolites. Long-lived gene mutations were generated in Drosophila yellow, and metabolites in wild and mutant Drosophila were measured by liquid chromatograph mass spectrometer (LCMS-8060NX) and gas chromatograph mass spectrometer (GCMS-TQ™ 8040 NX).

USEPA method 608 is GC-ECD method to determine Aroclor and organochlorine pesticides. This method requires the use of second column for confirming the detected compounds due to the low selectivity of the ECD detector comparing with GC-MS/MS. Also pattern recognition is required for accurate identification of Aroclors. Triple quadrupole GC-MS/MS based method offers a solution for the GC-ECD method’s drawbacks by providing high selective analysis. In addition, the type and concentration of Aroclor can be simultaneously determined.

For many forensic laboratories, there is a need for a simpler, faster and more effective way to conduct analysis. These labs face the challenge of delivering accurate results for an increasing number of samples. To improve productivity and confidence in results, they need more advanced instrumentation and software solutions designed specifically for forensic analysis.

Several chemicals found in fragranced products such as perfumes or shower gels are known to cause allergic reactions. Of these, 24 have been regulated by the EU. In this application note, discover an analytical method using GC/MS along with two columns of different polarity to identify a further 59 potential allergens in perfumes.

In this application note a triple quadrupole GC/MS/MS method using Multiple Reaction Monitoring (MRM) mode is used for sensitive and selective detection and quantitation of Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs); this is a common analysis in most environmental laboratories.

This application note describes the development of a Multiple Reaction Monitoring (MRM) instrument method using a commercially available triple quadrupole GC/MS/MS for detection and quantitation of N-nitrosamines after extraction as described by USEPA Method 521.

The triple-quad GCMS-TQ8030 is equipped with a scan/MRM mode that allows simultaneous full-scan and MRM data measurements. With this mode, target compounds are selectively determined from a MRM data and unknown compounds are identified from a full-scan data, respectively. This Application Data Sheet demonstrates the effectiveness of the scan/MRM mode when analyzing residual pesticides in a vegetable after QuEChERS extraction.

Contaminations of food and feed with persistent organic pollutants (POP), such as dioxons, are determined routinely by various analytical technologies. Dioxins are introduced via several ways into food products, for example eggs can be contaminated via the feed of hens. The current methods to determine the amount of dioxins and dioxin like substances is described in American and European legislations. In the past mainly gas chromatography coupled to high resolution mass spectrometry with isotopic dilution has been used as analytical method for analyzing and quantifying dioxins. In this application more than 50 samples of different matrices were split and analyzed by the Shimadzu GCMS-TQ8030 triple quadrupole mass spectrometer and the Waters Autospec GCHRMS.

This application note describes a method for extraction, identification, and quantitation of cocaine on paper money from nine different geographical areas around the globe, including five samples from the United States, using the Shimadzu GCMS-TQ8040 triple quadrupole mass spectrometer and the Multiple Reaction Monitoring (MRM) monitoring mode. Cocaine, a white crystalline alkaloid derived from the coca plant, is a popular illegal drug of abuse in the United States and elsewhere. Paper currencies around the world are usually made of a cellulose based paper which can adsorb cocaine onto the surface, and when a person handling cocaine subsequently touches paper money, or uses the bill as a tool to inhale cocaine, the currency easily becomes contaminated. When this contaminated paper money comes into contact with other bills, the cocaine is easily transferred from one bill to the next.

The GCMS-TQ8030 is a triple quadrupole GC-MS/MS system equipped with scan/MRM mode to allow simultaneous scan and MRM data measurements.This application note introduces the results of an investigation using the scan/MRM mode, where target pesticides were quantitatively determined using the MRM data, and concentrations of the untargeted pesticides were estimated by applying the scan data to the Compound Composer Database Software Ver.2.

Forensic spectroscopy encompasses a suite of analytical techniques designed to identify unknown substances and quantify trace elements with extreme precision and speed. In this SelectScience interview, Dr. Tom Spudich, Professor of Analytical Chemistry, explores how advanced tools like UV-Vis spectroscopy, GC-MS, FTIR with ATR, and ICP-OES are transforming forensic science workflows.

Discover how these methods are instrumental in diverse applications, from preserving historic documents through elemental analysis to detecting beverage adulterants like 1,4-butanediol. Learn how Shimadzu’s high-sensitivity instrumentation is slashing analysis times from hours to just 15 minutes, significantly boosting sample throughput and accessibility in the field.

Find out more information on Shimadzu forensics solutions here.

Watch this video to learn about the features of the Shimadzu GCMS-TQ8040, the first triple quadrupole with Smart Productivity for high efficiency sample throughput, Smart Operation for quick and easy method development, and Smart Performance for low detection limits and Scan/MRM.

An automated sample management system paired with a triple quadrupole mass spectrometer is said to drastically shorten analysis time