DynaPro™ Zetastar™ Dynamic, Electrophoretic, and Static Light Scattering Detector
Unique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Measure manually with microcuvettes, or automatically via an autosampler and flow cell. Quickly assess size, polydispersity, zeta potential, charge, particle concentration, molar mass or turbidity for characterization and s…
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Unique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Automate measurements of zeta potential and size for up to 96 samples at a time or measure manually with cuvettes with the walk-up touch screen functionality for optimal efficiency. Quickly quantify size, polydispersity, zeta potential/charge, particle concentration, molar mass or turbidity for characterization and stability studies.
Key Features:
- DYNAMICS Touch on-board app for walk-up, self-guided operation
- Pairable with a Waters HPLC and Pump to automate measurements of zeta potential and size
- Flow Mode for best-in-class zeta potential reproducibility and precision for samples in high salt buffers or prone to degradation
- Adaptive collection for faster and simpler measurements of zeta potential
- Measure size and turbidity with just 2 µL of solution, or zeta potential with as little as 65 µL of solution
- Measure zeta potential in buffers with conductivity up to 2x physiological saline
- A selection of high-quality quartz and disposable cells and cuvettes for both size and zeta potential measurements.
Automated, high-precision liposome zeta potential measurements at high and low salt concentrations
Zeta potential is used as a key metric for colloidal suspension stability for a wide range of applications. However, the general usefulness of zeta potential measurements has been held back by instruments limited to time-consuming, low-precision measurements within a narrow and often unsuitable ionic strength range.
In this application note, Wyatt Technology demonstrates how the DynaPro™ ZetaStar™ instrument allows scientists to go beyond these limitations, delivering automated measurements of biomolecule and nanoparticle zeta potential, size, and polydispersity at both low and high ionic strengths with excellent precision and accuracy.
A biopharmaceutical workflow powered by Wyatt Technology
Reliable biophysical characterization is a cornerstone of biologics development, playing a critical role at every stage – from selecting promising drug candidates to optimizing formulations and ensuring consistent manufacturing processes. Explore a comprehensive guide on how to deliver biopharmaceutical solutions, beginning with light scattering technology.
Particle size analysis by DLS for optimization of protein complexes for measurement by small-angle neutron scattering
Explore how dynamic light scattering (DLS) can be used to ensure monodispersity in protein samples for small-angle neutron scattering (SANS) studies. Discover how researchers using the DynaPro™ Plate Reader, detected protein aggregation that was undetectable by SDS-PAGE and UV spectroscopy. This method enhances sample quality assessment, ensuring reliable SANS measurements for studying Type I bacterial restriction-modification systems.
Measuring size, concentration, and zeta potential of LNPs with the DynaPro ZetaStar
Microfluidic formulation of RNA-containing lipid nanoparticles (LNP-RNA) is a common means of developing and producing this important non-viral modality of gene delivery. A key challenge during formulation is the selection of the specific lipids and formulation conditions to achieve the desired particle sizes and surface potential. Discover how by using the DynaPro™ ZetaStar™ instrument, researchers can rapidly characterize size, polydispersity, and zeta potential, comparing outcomes from two LNP formulation techniques to optimize efficiency and performance.
DynaPro ZetaStar: Automation, speed, and simplicity for nanoparticle characterization
In this video, Wyatt Technology demonstrates the power of automated nanoparticle characterization with the DynaPro™ ZetaStar™. Combining dynamic, electrophoretic, and static light scattering in one advanced system, it delivers precise measurements of size, polydispersity, zeta potential, particle concentration, molar mass, and turbidity, all in a single instrument. From viral vectors and lipid nanoparticles to proteins, polymers, and nucleic acids, the ZetaStar analyzes molecules ranging from angstroms to microns with speed and confidence.
Collaboration drives innovation in biotherapeutics
Waters and Wyatt Technology join forces to help accelerate the therapeutic pipeline and allow biotherapeutics to reach patients quicker
