Automated, high-precision liposome zeta potential measurements at high and low salt concentrations
18 Feb 2026Zeta potential is used as a key metric for colloidal suspension stability for a wide range of applications. However, the general usefulness of zeta potential measurements has been held back by instruments limited to time-consuming, low-precision measurements within a narrow and often unsuitable ionic strength range.
In this application note, Wyatt Technology demonstrates how the DynaPro™ ZetaStar™ instrument allows scientists to go beyond these limitations, delivering automated measurements of biomolecule and nanoparticle zeta potential, size, and polydispersity at both low and high ionic strengths with excellent precision and accuracy.
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DynaPro™ Zetastar™ Dynamic, Electrophoretic, and Static Light Scattering Detector
Waters | Wyatt TechnologyUnique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Measure manually with microcuvettes, or automatically via an autosampler and flow cell. Quickly assess size, polydispersity, zeta potential, charge, particle concentration, molar mass or turbidity for characterization and stability studies.