Bile Acids
Stable Isotope-labeled and Unlabeled Bile Acids
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CIL offers an extensive listing of unlabeled and stable isotope-labeled bile acids (BAs). These individuals span unconjugated and glycine/taurine conjugated BA classes, with some assembled into dried-down mixes to aid research use. Applications encompass their profiling and quantification to better understand host-gut microbial interactions that contribute to human health and disease states. Another example application could involve the study of bile acid synthesis, transport, and metabolism.
Rapid analysis of 17 bile acids in human plasma by LC-MS/MS
The quantitative analysis of bile acids in plasma is critical for diagnosing many structural liver diseases. Accurate reporting can be difficult because of analyte characteristics, matrix effects, and other factors. In this work, we describe a robust, selective LC-MS/MS method for the analysis of 17 bile acids in under 10 minutes, including three isomer groups, with special attention given to a matrix interference observed in routine human plasma analysis.
In this work, Cambridge Isotope Laboratories describes a robust, selective LC-MS/MS method for the analysis of 17 bile acids in under 10 minutes, including three isomer groups, with special attention given to a matrix interference observed in routine human plasma analysis.
Resource details:
- Resource type: Application note
- Page count: 12
- Read time: 18 mins
