6475 triple quadrupole LC/MS
The Agilent 6475 triple quadrupole LC/MS is the next step in evolution, building on the LC/TQ platform that customers trust most. The latest intelligent innovations will empower your lab to meet increasing sample throughput and productivity demands.
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Great sensitivity, rapid data acquisition and advanced ionization technology
Peptide separation
The 6475 Triple Quadrupole LC/MS is a cutting-edge instrument that redefines precision and reliability in mass spectrometry. Its unmatched sensitivity allows for accurate detection of trace analytes, while rapid data acquisition ensures high-throughput analyses without compromising quality. Advanced ionization technology minimizes background noise, providing clear spectra for confident identification and quantification. With user-friendly software and robust construction, the 6475 offers seamless integration and long-term stability, making it an indispensable tool for scientific research and industrial applications. Highly recommended for its exceptional performance and versatility.
Review Date: 16 Jul 2024 | Agilent Technologies
Excellent lab products for chromatography
Pesticides enviro forensic
Mass hunter easy software for cool chemists. Very good, economical, user friendly, less maintenance and no troubleshoots.
Review Date: 16 Jan 2024 | Agilent Technologies
Fast analysis, reliable results, professional team of engineer
Restricted substances testing on consumer product
The triple quadrupole LC/MS system can perform different types of analysis even in very low concentration and give reliable results, and their team including application engineers, maintenance engineers give a lot of help on method application and instrument maintenance. The design of Agilent's software is user friendly and efficient, it saves time not only on data analysis but also method development
Review Date: 4 May 2023 | Agilent Technologies
GREAT
Spectroscopy
After-sales care is quickly and the machine's efficiency is great.
Review Date: 4 May 2023 | Agilent Technologies
Easy to use for all users
Ecotoxicology
Easy to develop detection method with optimizer, after-sales department responds quickly, and the offer is lower than other manufacturers
Review Date: 3 May 2023 | Agilent Technologies
Excellent perforamce
Cannabis
Provide lots of application material
Review Date: 2 May 2023 | Agilent Technologies
Awesome product and great service!
Analytical chemistry
Great product! It was recently installed at my undergraduate serving institution. The support from Agilent has been top tier!
Review Date: 2 May 2023 | Agilent Technologies
Sufficient performance for research and university teaching courses Performance suffisante pour la recherche et les cours d'enseignement universitaire
Academic
Suitable for analyzes in university teaching courses (pharmaceutical samples) and academic research. The software platform is similar to what existed. An Agilent technician can be contacted for technical and maintenance issues either by phone or in person. Adéquat pour les analyses dans les cours de l'enseignement universitaire (échantillons pharmaceutiques) et recherches académiques . La plateforme du logiciel est similaire à ce qui existait. Un technicien d'Agilent est rejoignable pour des problèmes technique et de maintenance soit par téléphone ou en présence
Review Date: 2 May 2023 | Agilent Technologies
The best one known yet.
Analytical Chemistry Technology applications
Agilent 6475 LC/MS System:-- Was a much needed and awaited QUANTITATIVE lab equipment even before its arrival. Versatile instrument extending the dynamic range of mass analysis, speed, sensitivity, improved ionization and ion-trapping. These words are not fluff- transfer a quantitative LC-MS/MS method from any equivalent system to the Agilent 6475 system, and let the results speak for itself.
Review Date: 2 May 2023 | Agilent Technologies
Love this instrument!
Cannabis
This instrument has been extremely helpful and easy to use for method development and has no problems handling the cannabis matrix. The LC/MS specialist with Agilent have been amazing to work with. I would make this purchase again in a heartbeat.
Review Date: 2 May 2023 | Agilent Technologies
The Agilent 6475 triple quadrupole LC/MS is the latest evolution of the reliable LC/MS/MS workhorse customers trust the most. This sensitive, robust, and versatile triple quadrupole mass spectrometer employs several technological advantages like the superheated Agilent Jet Stream (AJS) ion source, curved and tapered collision cell, heated hyperbolic quadrupoles, and ± 20 kV high-energy dynode detector system. The 6475 LC/TQ also features instrument intelligence technologies such as early maintenance feedback, scheduled tune and check-tune, and intelligent secondary injection workflows.
Through advanced hardware, required limits of detection for the analysis of pesticides, veterinary drugs, PFAS, nitrosamines, and other regulated methods can easily be achieved day in and day out. Coupled with sophisticated, yet easy to use onboard instrument intelligence, your lab can maximize uptime, maintain peak instrument performance, help anticipate maintenance events, and achieve confidence in your results.
Features:
- Multiple versatile and easy-to-configure ion sources including AJS, ESI, APCI, and MMI allow you to tackle any type of LC/MS analysis
- Wide mass range allows the analysis of ions of various classes and sizes, from small molecules to multiply charged peptides
- VacShield allows you to do front-end ion injector maintenance without breaking vacuum, drastically reducing routine maintenance from at least 6 hours to 30 minutes
- Early maintenance feedback (EMF) provides instrument health and status reports by reporting actively monitored metrics so you can anticipate downtime or address an immediate issue
- Intelligent Reflex ensures that results are within operational limits through active monitoring of sample carryover and samples above calibration range, adding additional blanks or reducing sample volume if one of these conditions is met
- Fast screening workflow with Intelligent Reflex dramatically improves sample throughput with a shortened LC method for screening and a standard method for quantitation; if a target is detected during screening, the sample is reinjected using a standard quantitation method.
- Built-in technical controls combined with procedural controls ensure the security of your data, control access, and facilitate compliance as defined by US FDA 21 CFR Part 11, EU Annex 11, and similar national electronic record regulation
Brochures
Agilent 6475 triple quadrupole LC/MS: Unbelievably powerful, remarkably intelligent
In this product brochure, learn more about the Agilent 6475 triple quadrupole LC/MS. Discover innovative features such as onboard intelligence providing immediate validation of results to improve speed of analysis and time-saving automation software that lets you schedule calibration in advance.
Intelligent Reflex Fast Screening for drugs in urine: Data-dependent reinjection logic for screening and confirmation of presumptive positives
In this scientific poster, Agilent Technologies introduces Intelligent Reflex, a data-dependent worklist reinjection logic system built into MassHunter 12 for LC/TQ and LC/QTOF. The poster showcases the Fast Screening workflow and its potential to increase productivity for large sample batches.
What stops pharma labs from reaching their full potential?
In this application note, Agilent Technologies has teamed up with Frost & Sullivan and conducted a global survey focusing on the challenges and pain points that labs deal with every day. Download the results of the survey to find out what pharma lab leaders are most concerned about.
Agilent 6475 LC/TQ performance highlights with EPA draft method 1633 for per and polyfluoroalkyl substances (PFAS) in solid samples
In this application note, Agilent Technologies details the performance of its 6475 Triple Quadrupole LC/MS (LC/TQ) system coupled with the Agilent 1290 Infinity II liquid chromatograph (LC) system for the analysis of per- and polyfluoroalkyl substances (PFAS) in accordance with the third draft of EPA 1633. Method transfer between the Agilent 6475 and 6470 B triple quadrupole LC/MS systems was seamless, and the new intelligent source optimization algorithm was tested, as the EPA 1633 analyte list includes thermally sensitive compounds. Calibration linearity and reproducibility were verified, and the results met all method requirements. The same soil extracts were analyzed on both systems (6470 B and 6475 LC/TQ) to demonstrate comparable performance. Finally, instrument robustness was challenged by >1,000 noninterrupted injections of extracted fish samples while monitoring calibration verification standards after every 50 injections of matrix.
Determination of nitrosamine impurities using the Agilent 6475 Triple Quadrupole LC/MS system
Nitrosamine impurities are by-products that are produced in trace amounts during the manufacturing process of pharmaceutical drugs. These impurities are classified as potentially genotoxic impurities and probable carcinogens with long-term intake. Therefore, it is important to determine their levels in final drug products with a high level of sensitivity and confidence. In this application note, Agilent Technologies evaluates the quantification performance of eight nitrosamine impurities using the Agilent 6475 Triple Quadrupole LC/MS (LC/TQ) system coupled with the Agilent 1290 Infinity II Bio LC system and atmospheric pressure chemical ionization (APCI) source.
What lab managers want
In this infographic, explore results from Agilent’s independent global survey of lab managers from different market segments titled ‘Understanding Key Challenges and Pain Points in the Global Laboratory Market’.
Advances in mass spectrometry instrument intelligence
In this poster collection, Agilent Technologies take a deep dive into the next evolution of its LC/MS instrument portfolio. It will demonstrate how the new intelligence features can improve analytical performance and lab productivity, providing you with peace of mind for day‑to-day operation.
Method development and evaluation for multiresidue pesticide analysis in foods using the 6475 Triple Quadrupole LC/MS system
Agilent Technologies describes the development and evaluation of a comprehensive LC/MS/MS method for over 500 pesticide analyses in three food matrices (wheat, olive oil, and black tea). The work was completed using the Agilent 6475 triple quadrupole LC/MS (LC/TQ) system coupled with the Agilent 1290 Infinity II Bio LC system and MassHunter Workstation 12.0.
Active & iterative data-dependent reinjection logic for maintaining throughput, uptime, and consistency in triple quadrupole LC/MS analysis
The 6475 triple quadrupole LC/MS system with MassHunter 12 features an intelligent workflow called iReflex, an intelligent automated worklist reinjection logic tool to maximise analytical throughput or ensuring samples are within tolerance.
In the application note, Agilent Technologies demonstrates three iReflex workflows, that can operate concurrently in one worklist to ensure samples are measured within SOP guidelines.
Accelerated lifetime testing with real-time Early Maintenance Feedback (EMF) diagnostic monitoring on the 6475 triple quadrupole LC/MS
To help alleviate concerns on instrument health and longevity, the new Agilent 6475 triple quadrupole LC/MS system was designed with onboard intelligence that actively reports on the instrument health and status through Early Maintenance Feedback (EMF).
In this application note, Agilent Technologies presents a use case to trigger EMF events to simulate heavy instrument use through 10,000 sample injections of spiked bovine urine.
An end-to-end software algorithm for LC/MS/MS method development, optimization, and QA/QC deployment
The new 6475 triple quadrupole LC/MS system with MassHunter 12 includes an intelligent MRM and source optimizer that is built into the method editor.
In this application note, Agilent Technologies demonstrates that this intelligent optimizer can be used to create a new method from scratch, add new components ton an existing method, and fine tune or verify parameters of an existing method.
How Weck Laboratories stays ahead in PFAS testing
In this video, Agustin Pierri, laboratory technical director at Weck Laboratories, addresses the challenges associated with low-level quantitation of per- and polyfluoroalkyl substances (PFAS). These compounds, widely used in various products, have become pervasive in the environment and human tissues globally. Dr. Pierri discusses the difficulties related to representative sampling and contamination prevention when quantifying PFAS at low levels and emphasizes the use of Agilent triple quadrupole LC/MS systems to tackle these challenges effectively.
Sustainable solutions for life science research
In this video, Agilent Technologies emphasizes the importance of sustainability in life science research, and introduces its adjuvant chromatography instruments, which are built sustainably and designed to be resource efficient. Agilent Technologies has collaborated with My Green Lab to achieve excellent results with the ACT label (accountability, consistency, and transparency), a Global Green Accreditation.
Sustainable solutions from Agilent Technologies
In this video, Agilent Technologies presents its sustainable solutions to boost your research.
Unbelievably powerful, remarkably intelligent: The Agilent 6475 triple quadrupole LC/MS
In this video, Agilent Technologies introduces the Agilent 6475 triple quadrupole LC/MS, one of the most intelligent additions to the Agilent LC/MS portfolio, designed to help you keep up with your lab goals.
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