Electron microscopy (EM) is used to create high-resolution images of samples at the nanoscale, using an accelerated beam of electrons as a source of illumination. Cryo-EM is used to view samples prepared under cryogenic conditions and is becoming an essential technology within many fields, especially structure-based drug discovery. In this article, we take a closer look at some of the latest advancements and applications of cryo-EM technology within the pharmaceutical industry. Plus, 2017 Nobel Prize winner in chemistry, Dr. Richard Henderson, highlights just how important cryo-EM is within science as a whole.
Learn how AstraZeneca is adopting cryo-EM to expand its targets for drug discovery
In this article, Dr. Chris Phillips, structural biologist and Associate Director at AstraZeneca, discusses how cryo-EM might be a ‘game-changer’ for elucidating protein structure where current conventional crystallographic approaches fall short.
In this exclusive interview for The Scientists’ Channel, watch Dr. Richard Henderson, 2017 Nobel Prize winner in chemistry, discuss the growing importance of cryo-electron microscopy for science and how leading pharmaceutical companies are working together to utilize this revolutionary technique at the newly opened Cryo-EM suite at eBIC at Diamond Light Source, Harwell Science and Innovation Campus.
In this SelectScience interview, we talk with Dr. Claudio Ciferri, structural biologist, crystallographer and head of cryo-EM at Genentech, about drug discovery through investigation of the structure and function of challenging protein targets. Ciferri explains how the use of cryo-EM is enabling his team to tackle many targets that are otherwise impossible to visualize.
In this application-based eBook, we outline the application of cryo-EM in structure-based drug discovery and look at how state-of-the-art microscopes, such as the Krios G4 cryo-TEM from Thermo Fisher Scientific, help to keep leaders in the pharmaceutical industry at the forefront of drug discovery.
In this application note, Thermo Fisher Scientific highlights how your lab could benefit from using cryo-EM technology.
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