Krios G4 Cryo-TEM for Life Sciences
The Thermo Scientific Krios G4 Cryo-Transmission Electron Microscope (Cryo-TEM) is a compact TEM. The instrument can be installed in labs with a ceiling height below 3.04 m (~10 ft), as the microscope height it below 3 meters. The Krios G4 Cryo-TEM has improved ergonomics for easier sample exchange. Data acquisition set up is easier and faster thanks to enhanced automation, systematic user guidance and advanced performance mo…
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High productivity in a compact design
The Thermo Scientific Krios G4 Cryo-Transmission Electron Microscope (Cryo-TEM) is a compact TEM. The instrument can be installed in labs with a ceiling height below 3.04 m (~10 ft), as the microscope height it below 3 meters.
The Krios G4 Cryo-TEM has improved ergonomics for easier sample exchange. Data acquisition set up is easier and faster thanks to enhanced automation, systematic user guidance and advanced performance monitoring. Simultaneously, the system’s productivity and high-resolution performance have been further enhanced through a combination of new optical modes, improved optical specifications and on-the-fly pre-processing.
Enhanced productivity
- Improved drift performance allows for a 3x faster experiment start.
- Powerful combination of fringe-free imaging (FFI), aberration-free image shift (AFIS) and the (optional) Thermo Scientific Falcon™ 4 Direct Electron Detector enhances single particle analysis throughput by up to 400%.
Image quality
Optical performance: 0.12 nm information limit and linear distortion of <0.5%
Go beyond structure & understand function with cryo-electron microscopy
Learn more about adopting cryo-EM and how it can advance your research in this new ebook from Thermo Fisher Scientific. Cryo-EM can determine structures of challenging proteins without the need for crystals and can provide insight into how these proteins function in a way that other methods simply cannot. Use cryo-EM to get a broader picture of how membrane proteins function and contribute to disease to drive your research and improve drug design.
Why invest in cryo-EM?
How will your lab benefit from investing in cryo-EM?
Structure-based drug discovery with cryo-EM
Cryo-electron microscopy (cryo-EM) is a powerful biophysical technique that allows researchers to visualize molecular assemblies at near-atomic resolution. In this application-based eBook, we outline the application of cryo-EM in structure-based drug discovery and look at how state-of-the-art microscopes, such as the Krios G4 cryo-TEM from Thermo Fisher Scientific, help to keep leaders in the pharmaceutical industry at the forefront of drug discovery.
Download this eBook to learn more about:
- The single-particle analysis (SPA) workflow
- Micro-electron diffraction (microED) using nanocrystals
- The applications of cryo-EM in structure-based drug design
- Scientists who are using this technique, including Nobel laureate Dr. Richard Henderson
Applications of cryo-electron microscopy
In this application note, Thermo Fisher Scientific introduces the versatility of cryo-EM and the variety of benefits made possible by this method. This application outlines how cryo-EM provides a better insight into all classes of biomolecules, including proteins that are difficult to work with.
Requirements for preparation of cryo-EM samples
In this application note, Thermo Fisher Scientific outlines a step-by-step guide to the requirements for sample preparation in cryo-electron microscopy (cryo-EM) to ensure the collection of high-resolution data.
MicroED and drug discovery
In this application note, Thermo Fisher Scientific outlines the method of micro-electron microscopy (microED) and the possibilities that microED has in the determination of the structure of proteins.
Practical recommendations for cryo-EM single particle analysis reconstruction
In this application note, Thermo Fisher Scientific details the main principles of image processing for single particle analysis (SPA) and details practical solutions to this rapidly evolving computational landscape. Multiple software packages have been suggested to combat the large data sets of electron microscopy images acquired and correlated during cryo-electron microscopy (cryo-EM) SPA.
Thermo Fisher Scientific and Structura Biotechnology collaborate to offer a solution for real-time cryo-EM data analysis
New Embedded CryoSPARC Live software to be made available by Structura and Thermo Fisher and designed to integrate with Thermo Fisher technology
Accelerating targets and modalities – how cryo-EM is transforming drug discovery and development
In this guest editorial article, learn how scientists are leveraging cutting-edge cryo-EM workflow advancements and their impact in drug discovery
Thermo Fisher’s iSPA workflow aims to provide faster drug discovery results
Reliable, easy-to-use cryo-EM workflow solution promises to quadruple throughput for pharma labs
Trends in Cryo-EM: How cryo-electron microscopy technology is revolutionizing the drug discovery industry
Discover the latest advances and top resources in cryo-EM, from elucidating protein structure to single particle analysis reconstruction
How the pharma industry is harnessing cryo-electron microscopy in drug discovery
Learn how AstraZeneca is adopting nascent cryo-electron microscopy (cryo-EM) technology to expand its targets for drug discovery
Trending in drug discovery and biopharma - the best of 2019
From CRISPR screening in primary T cells to photodynamic therapy for curing cancer, we take a look back at research highlights and emerging technologies from the past year
Delivering the undeliverable: Enabling structural drug discovery through high-resolution cryo-electron microscopy (cryo-EM)
Meet one of the first cryo-EM groups set on delivering a resolution revolution
