Applications of cryo-electron microscopy
Cryo-electron microscopy (cryo-EM) allows the structural analysis of protein complexes flash-frozen in their near native states. You can now directly visualize not just large macromolecules but also smaller proteins complexes, including membrane proteins. This powerful technique can be used to complement traditional methods, such as X-ray crystallography (XRD) or nuclear magnetic resonance (NMR) for structure based drug discovery
22 Sept 2019In this application note, Thermo Fisher Scientific introduces the versatility of cryo-EM and the variety of benefits made possible by this method. This application outlines how cryo-EM provides a better insight into all classes of biomolecules, including proteins that are difficult to work with.
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