Glacios™ Cryo-TEM for Life Sciences
The new Thermo Scientific™ Glacios™ Cryo Transmission Electron Microscope (Cryo-TEM) delivers a complete and affordable Cryo-EM solution to a broad range of scientists.
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The new Thermo Scientific™ Glacios™ Cryo Transmission Electron Microscope (Cryo-TEM) delivers a complete and affordable Cryo-EM solution to a broad range of scientists. It features 200 kV XFEG optics, the industry-leading Autoloader (cryogenic sample manipulation robot) and the same innovative automation for ease of use as on the Krios G3i Cryo-TEM. The Glacios Cryo-TEM bundles all this into a small footprint that simplifies installation. The designed-in connectivity ensures a robust and contamination-free pathway throughout the entire workflow, from sample preparation and optimization to image acquisition and data processing. The Glacios Cryo-TEM can used in a single particle analysis (SPA) workflow for pre-screening of sample quality before transferring to the Krios Cryo-TEM for ultimate-resolution SPA data acquisition. Furthermore the Glacios Cryo-TEM can also be configured with a Direct Electron Detector and/or Volta Phase Plate to be a complete standalone SPA data acquisition solution.
Small footprint
The new hardware architecture of the Glacios has been specifically designed to address the need for a smaller footprint and easier access path. In many cases, this design avoids the additional investment and unwanted lab downtime for significant modifications to an existing infrastructure or the need for a purposely-built lab.
Enhanced ease of use through automation
The Glacios Cryo-TEM reduces the number of complex alignments that a user has to perform. For recurring alignments that need to be done regularly, automated alignment routines have been implemented into the EPU software for SPA. The EPU user interface has been further streamlined to provide a comprehensive user guide.
Reproducible, optimal tool performance always guarantee
The optimal thermal and mechanical stability of the Glacios Cryo-TEM ensure perfect optical performance. The instrument features a self-assessment function that automatically evaluates the optical status of the microscope, providing feedback for any steps that require optimization. Additionally, automated alignment routines allow the instrument to be tuned to its optimal starting point for SPA or tomography experiments.
Maximum Throughput
EPU is the native software package for automated screening and acquisition of large data sets on the Thermo Fisher cryo-TEMs. With full control of the Autoloader from within EPU, all grids in a cassette can be batch-screened: after the creation of a grid atlas, ice quality (presence, thickness) of the vitrified grids is automatically categorized to support a guided selection of grid squares.
Workflow Connectivity
For successful cryo-EM data acquisition, optimization of both biochemistry and vitrification requires an efficient screening process. The Glacios Cryo-TEM is designed to be integrated into an SPA workflow – it can be used for sample evaluation and optimization, before high-resolution data acquisition. The data acquisition can occur directly on the Glacios Cryo-TEM, or in a Krios or Arctica Cryo-TEM – after sample transfer
The Autoloader capsule and cassette systems ensure a robust and contamination-free transfer of samples between Glacios, Arcita and Krios Cryo-TEMs, without the need for manipulation of individual small grids.
Go beyond structure & understand function with cryo-electron microscopy
Learn more about adopting cryo-EM and how it can advance your research in this new ebook from Thermo Fisher Scientific. Cryo-EM can determine structures of challenging proteins without the need for crystals and can provide insight into how these proteins function in a way that other methods simply cannot. Use cryo-EM to get a broader picture of how membrane proteins function and contribute to disease to drive your research and improve drug design.
Why invest in cryo-EM?
How will your lab benefit from investing in cryo-EM?
Structure-based drug discovery with cryo-EM
Cryo-electron microscopy (cryo-EM) is a powerful biophysical technique that allows researchers to visualize molecular assemblies at near-atomic resolution. In this application-based eBook, we outline the application of cryo-EM in structure-based drug discovery and look at how state-of-the-art microscopes, such as the Krios G4 cryo-TEM from Thermo Fisher Scientific, help to keep leaders in the pharmaceutical industry at the forefront of drug discovery.
Download this eBook to learn more about:
- The single-particle analysis (SPA) workflow
- Micro-electron diffraction (microED) using nanocrystals
- The applications of cryo-EM in structure-based drug design
- Scientists who are using this technique, including Nobel laureate Dr. Richard Henderson
Applications of cryo-electron microscopy
In this application note, Thermo Fisher Scientific introduces the versatility of cryo-EM and the variety of benefits made possible by this method. This application outlines how cryo-EM provides a better insight into all classes of biomolecules, including proteins that are difficult to work with.
Requirements for preparation of cryo-EM samples
In this application note, Thermo Fisher Scientific outlines a step-by-step guide to the requirements for sample preparation in cryo-electron microscopy (cryo-EM) to ensure the collection of high-resolution data.
MicroED and drug discovery
In this application note, Thermo Fisher Scientific outlines the method of micro-electron microscopy (microED) and the possibilities that microED has in the determination of the structure of proteins.
Practical recommendations for cryo-EM single particle analysis reconstruction
In this application note, Thermo Fisher Scientific details the main principles of image processing for single particle analysis (SPA) and details practical solutions to this rapidly evolving computational landscape. Multiple software packages have been suggested to combat the large data sets of electron microscopy images acquired and correlated during cryo-electron microscopy (cryo-EM) SPA.
Accelerating targets and modalities – how cryo-EM is transforming drug discovery and development
In this guest editorial article, learn how scientists are leveraging cutting-edge cryo-EM workflow advancements and their impact in drug discovery
Thermo Fisher’s iSPA workflow aims to provide faster drug discovery results
Reliable, easy-to-use cryo-EM workflow solution promises to quadruple throughput for pharma labs
Trends in Cryo-EM: How cryo-electron microscopy technology is revolutionizing the drug discovery industry
Discover the latest advances and top resources in cryo-EM, from elucidating protein structure to single particle analysis reconstruction
How the pharma industry is harnessing cryo-electron microscopy in drug discovery
Learn how AstraZeneca is adopting nascent cryo-electron microscopy (cryo-EM) technology to expand its targets for drug discovery
Trending in drug discovery and biopharma - the best of 2019
From CRISPR screening in primary T cells to photodynamic therapy for curing cancer, we take a look back at research highlights and emerging technologies from the past year
Delivering the undeliverable: Enabling structural drug discovery through high-resolution cryo-electron microscopy (cryo-EM)
Meet one of the first cryo-EM groups set on delivering a resolution revolution
