Here are Tom’s lab essentials:
1. Xevo G2 QTof with ACQUITY UPLC H-Class System from Waters
Combining the Xevo G2 QTof with the ACQUITY UPLC H-Class System enables good separation with short run times, and allows us to obtain accurate MS data on DNA oligonucleotides. The high sensitivity of the Xevo G2 QTof allows us to interrogate impurities arising from oligonucleotide synthesis; this information allows us to optimize DNA synthesis and ultimately to produce better quality oligonucleotides.
2. Shimadzu Prominence LC-20AP Preparative HPLC system
Powerful, good value, easy to use prep. HPLC system with intuitive software.
3. ThermoMixer® C from Eppendorf
These versatile temperature-controlled mixers are useful for all kinds of chemical reactions in different vessels. We use them extensively for DNA labelling and enzyme reactions.
4. CLARIOstar multi-mode microplate reader from BMG LABTECH
Microplate reader with monochromator, spectrometer, and filters. We make DNA with many different fluorescent dyes, and the monochromator allows us to measure fluorescence intensity at different emission/absorbance wavelengths without needing a separate filter for each dye. Can also be measure emission and absorbance spectra, and for routine UV measurements.
5. OligoPilot™ 400 from GE Healthcare
An automated system for the large-scale synthesis of DNA and RNA oligonucleotides.
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