This application note presents a method for the extraction of AM2201 and metabolites in urine. LC/MS/MS instrumentation is used for analysis with a linear range of 1 ng/mL to 100 ng/mL with average recoveries found to be greater than 90%.
Clean Screen® Xcel Well Plates The Clean Screen Xcel products are a line of sample prep phases designed to reduce the number of steps in the extraction, and therefore the amount of time and solvent necessary to complete the sample cleanup. Further advantages include reduced sample size and improved cleanliness and recovery. The Xcel I well plate will extract a wide array of basic drugs including benzodiazepines and opiates. The Xcel II well plate is designed solely for the extraction of the THC metabolite.
Clean Screen® DAU Solid Phase Extraction Column is the flagship product of the forensic solid phase extraction column line. The first product of its kind in the industry, it is a mixed-mode column exhibiting both hydrophobic and cation exchange characteristics. Over 20 years of experience has shown this column to be effective on hundreds of drugs in both the acid-neutral and basic drug categories.
The Clean Screen® FASt column is a novel approach to improved sample preparation for LC/MS analysis. The column employs a one step process to prepare urine samples for analysis of multiple drugs and metabolites. By quickly and efficiently reducing the amount of unwanted matrix and particulates in the final sample, the analysis can proceed with less chance of matrix suppression and LC column clogging.
The Clean Screen® XCEL Solid Phase Extraction Columns are a line of sample prep phases designed to reduce the number of steps in the extraction, and therefore the amount of time and solvent necessary to complete the sample cleanup. Further advantages include reduced sample size and improved cleanliness and recovery. The Xcel I column will extract a wide array of basic drugs including benzodiazepines and opiates. The Xcel II column is designed solely for the extraction of the THC metabolite.
Styre Screen® Extraction Columns contain an ultra clean, highly cross-linked styrene and divinylbenzene copolymer. The Styre Screen particles have an average particle size of 30 microns and a very high analyte capacity making them ideal for standard solid phase extraction applications. The increased analyte capacity means that less sorbent bed mass is needed which results in faster flow rates and less solvent use. Higher throughput and less solvent waste disposal translate into significant savings in both time and money. In addition, no conditioning steps are required for most analyte applications. Styre Screen® Extraction Columns Advantages: Copolymer allows for extraction of acids, neutrals and bases High and reproducible recoveries Clean extractions Highly cross-linked styrene/divinylbenzene polymer Reduction in sorbent mass Faster flow rates pH stable (1 to 14) Reduction in solvent use High sorbent capacity Methods for NIDA/SAMHSA 5 Drugs
