How to achieve a robust method for GLP-1 agonist tirzepatide using YMC Accura Triart Bio C18
13 Oct 2026This application note presents a structured method development workflow for the analysis of tirzepatide, a dual GLP-1 and GIP receptor agonist used in the treatment of type 2 diabetes. Learn how mobile phase composition, pH, column temperature, stationary phase chemistry and column hardware influence chromatographic performance. Discover how the bioinert YMC Accura Triart Bio C18 column improved peak shape, recovery and resolution, enabling a robust and reproducible method for tirzepatide purity testing and supporting analytical development for other GLP-1 receptor agonists.
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Resource type: Application note
Page count: 7
Read time: 10 mins
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(Bio)inert RP/HILIC (U)HPLC Columns: YMC Accura Triart
YMC EuropeBioinert YMC Accura Triart RP and HILIC columns are available for the analysis of critical substances including selected proteins, (oligo)nucleotides and metal-coordinating compounds such as organophosphates.