Importance of hardware selection in peptide analysis including GLP-1 receptor agonists

This application note investigates the impact of column hardware on peptide analysis, with a focus on GLP-1 receptor agonists including liraglutide, semaglutide, retatrutide and tirzepatide. Learn how interactions between peptides and conventional stainless-steel HPLC hardware can lead to analyte adsorption, peak broadening and reduced sensitivity. Discover how bioinert YMC Accura column hardware minimizes metal-analyte interactions, improves peak shape and signal intensity, and enhances quantitative performance, particularly for LC-MS applications and low-concentration peptide analysis.

Resource details:

Resource type: Application note
Page count: 10
Read time: 12 mins