Inertsil Hybrid-C18: high-pH tolerant HPLC column for robust and reproducible performance
13 Oct 2026This product brochure introduces Inertsil Hybrid-C18, a silica-based reversed-phase HPLC column engineered with hybrid organic-inorganic technology for exceptional stability across a broad pH range of 1-12. Explore how the column combines high durability under alkaline conditions with compatibility for 100% aqueous mobile phases, enabling reliable analysis of basic, acidic and metal-coordinating compounds. Discover its excellent batch-to-batch reproducibility, LC/MS compatibility, bioinert PEEK hardware options, and application versatility for pharmaceutical, biopharmaceutical, and analytical testing workflows.
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Resource type: Product brochure
Page count: 8
Read time: 12 mins
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Inertsil Hybrid-C18 LC Column
GL Sciences, Inc.Inertsil Hybrid-C18 is a high-pH resistant HPLC column that enables stable and reproducible separations across a wide pH range (1–12). Built with hybrid silica technology, it ensures excellent peak shapes even for basic analytes and provides superior lifetime compared to conventional C18 columns. Available in 1.7 µm, 3.5 µm, and 5 µm, it is ideal for LC-MS and method development.