Semi-automated medium exchange in Akura 96 and 384 Spheroid Microplates with the VIAFLO 96 and VIAFLO 384
6 Jul 2026This application note describes a semi-automated workflow for medium exchange in 3D spheroid cultures using Akura™ microplates and VIAFLO® multichannel pipetting systems. The approach enables precise liquid handling while preserving spheroid integrity, supporting reproducible and scalable 3D cell culture workflows.
The system combines specialized microplate design with controlled pipetting parameters to minimize spheroid loss and improve experimental consistency. This enables efficient handling of high-throughput assays and long-term cultures, making it well suited to applications in drug discovery, toxicology, and disease modeling.
Resource details:
- Resource type: Application note
- Page count: 7
- Read time: 11 mins
Related products
Request Quote for All Products
Akura™ 96 Spheroid Microplate
InSpheroThe Akura™ 96 Spheroid Microplate is our most commonly used handling plate for daily spheroid culture in every lab environment, from manual to automated handling. The plate is designed for lossless spheroid formation and handling as well as reliable cell culturing and analysis.
Akura™ 384 Spheroid Microplate
InSpheroThe Akura™ 384 Spheroid Microplate is our ultimate spheroid screening plate unifying robust liquid and spheroid handling with automated high-throughput screening applications. The flat bottom and black walls of the InSphero 384-well plate facilitate fluorescent imaging, while the special well design allows medium exchange, dosing, and endpoint determination in the same plate saving time and resources.