ResourceDrug Discovery & Development
Innovative Octet Biolayer Interferometry approach for non-disruptive and fast AAV capsid ratio determination in complex biological matrices
22 Oct 2026Explore a biolayer interferometry (BLI) approach for determining empty-to-full capsid ratios in adeno-associated virus (AAV) samples. Learn how differences in binding signals between empty and genome-containing capsids can be used to assess capsid ratios without disrupting the viral particles or separately determining DNA titer. Discover how the method performs across multiple AAV serotypes and biological matrices, including crude cell lysate, and how it can support rapid, high-throughput AAV characterization.
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Resource type: Article
Page count: 6
Read time: 5 mins
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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.aav